Publications by authors named "L Chatre"
Article Synopsis
- * The study investigated NR's effects using various models that simulate oxidative stress, aging, and AD, focusing on neuronal survival and the complex interactions of reactive species.
- * Findings reveal that NR treatment affects specific protein networks related to energy metabolism and neurotransmitter regulation, suggesting potential pathways for modifying the disease processes in AD.
Article Synopsis
- Preeclampsia (PE) is a pregnancy-related condition defined by issues like high blood pressure, protein in urine, and problems with the placenta, and is modeled in mice by the overexpression of the STOX1A transcription factor.
- Research shows that STOX1A overexpression disrupts nitric oxide production and mitochondrial function in trophoblasts, which leads to a disturbance in the Krebs cycle and lower levels of a key metabolite, l-malate.
- Administering tetrahydrobiopterin (BH4) restores these disrupted processes in vitro and in rodent models, suggesting BH4 could be a promising treatment for alleviating symptoms of preeclampsia, such as placental
Redox pioneer Helmut Sies attempted to explain reactive species' challenges faced by organelles, cells, tissues, and organs three complementary definitions: (i) oxidative stress, that is, the disturbance in the prooxidant-antioxidant defense balance in favor of the prooxidants; (ii) oxidative eustress, the low physiological exposure to prooxidants; and (iii) oxidative distress, the supraphysiological exposure to prooxidants. Identification, concentration, and interactions are the most important elements to improve our understanding of reactive species in physiology and pathology. In this context, the reactive species interactome (RSI) is a new multilevel redox regulatory system that identifies reactive species families, reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species, and it integrates their interactions with their downstream biological targets.
View Article and Find Full Text PDFMitochondrial physiology and metabolism are closely linked to replication and transcription of mitochondrial DNA (mtDNA). However, the characterization of mtDNA processing is poorly defined at the single-cell level. We developed mTRIP (mitochondrial Transcription and Replication Imaging Protocol), an imaging approach based on modified fluorescence in situ hybridization (FISH), which simultaneously reveals mitochondrial structures committed to mtDNA initiation of replication as well as the mitochondrial RNA (mtRNA) content at the single-cell level in human cells.
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