Publications by authors named "L Champion"
Article Synopsis
- This study evaluated how certain biomarkers from pretreatment PET/CT scans relate to patient outcomes in those with metastatic breast cancer (mBC) receiving specific antibody-drug conjugates (ADCs) - Sacituzumab Govitecan (SG) and Trastuzumab Deruxtecan (T-DXd).
- Conducted on 128 patients, the research found that higher levels of total metabolic tumor volume (TMTV) and maximum tumor dissemination (Dmax) were linked to shorter overall survival (OS) and progression-free survival (PFS) in both treatment groups.
- The conclusion highlights the potential of these biomarkers for improving survival predictions and tailoring treatment plans for mTNBC and
Article Synopsis
- Immunogenicity guidance in the biopharmaceutical industry has evolved significantly over the past 20 years due to initial negative reactions with erythropoietin, leading to stringent practices for all biotherapeutic drugs.
- A recent workshop by the European Bioanalysis Forum highlighted the need to reassess current immunogenicity testing methods, drawing from two decades of experience to suggest more relevant approaches.
- The proposed new paradigm encourages a context-based assessment of immunogenicity risk, viewing it as a pharmacodynamic biomarker, which aims to streamline testing strategies and better allocate resources for patient benefit.
The European Bioanalysis Forum, in collaboration with several key industry stakeholders, has recently led discussions that address international immunogenicity guidance documents, specifically the three tier approach for immunogenicity testing strategies, after more than 20 years of experience with biotherapeutics. As part of this, the strategy and methods used to assess drug tolerance across all immunogenicity assays are challenged, emphasizing that bioanalytical scientists need to consider the context-of-use of each assay. Here, recommendations for drug tolerance assessments, driven by strong scientific rationale and subject to reevaluation as needed, are provided.
View Article and Find Full Text PDFBecause they hold information about cultural identity, foodways have been the focus of a variety of disciplines in archaeology. However, each approach documents different stages of culinary preparation and is constrained by the preservation specificities of each type of artefact and ecofact. Difficulties in achieving an interdisciplinary approach may explain the scarcity of such studies.
View Article and Find Full Text PDFArticle Synopsis
- Radiation therapy is important for treating advanced lung cancer, but it can cause a problem called radiation pneumonitis (RP), which affects breathing.
- A study looked at 80 articles to find out how doctors can use tests to predict who might get RP and to help plan better treatments.
- The study found that older patients and those with certain lung conditions had a higher risk of RP, and they suggested a checklist to help identify patients at risk before treatment starts.