Oncologic reconstructive surgery of the talus with structural allograft: Case report.

Introduction And Importance: Introduction and importance: Bone tumors of the foot constitute 3 % of all bone tumors, within these, the location in the talus constitutes between 8 and 23 % of bone tumors. Within the oncological management of these lesions, preservation surgery has had a great boom in the last 10 years, however, the use of massive structural allograft is not a conventional surgery and there is little literature on its use, which is why we consider important to document clinical cases.

Case Presentation: we document 2 clinical cases of bone tumor in the talus that were surgically managed with tumor resection plus reconstruction with total and partial talus allograft.

ED Nurse-Led Code Sepsis to Reduce Time to Antibiotics.

Background: Delays in sepsis recognition contribute to delays in antibiotic administration, which lead to increased morbidity and mortality in patients with sepsis. Our objective was to create an Emergency Department (ED) Code Sepsis Nurse-led team to reduce the time to antibiotics and mortality in patients with sepsis.

Methods: This initiative was implemented at a community hospital in Southern California in response to previous undesirable sepsis outcomes.

Unlocking the Potential of Senolytic Compounds: Advancements, Opportunities, and Challenges in Ageing-Related Research.

Cellular senescence is recognised as a contributor to the ageing process and the development of multiple age-related conditions. Researchers have launched efforts to identify compounds capable to selectively kill senescent cells, known as senolytics, without affecting non senescent cells. As of now, over 40 compounds have demonstrated senolytic properties, offering promising prospects for reversing or ameliorating age-related conditions in preclinical studies.

Dataset of Sentinel-1 SAR and Sentinel-2 RGB-NDVI imagery.

This article presents a comprehensive dataset combining Synthetic Aperture Radar (SAR) imagery from the Sentinel-1 mission with optical imagery, including RGB and Normalized Difference Vegetation Index (NDVI), from the Sentinel-2 mission. The dataset consists of 8800 images, organized into four folders-SAR_VV, SAR_VH, RGB, and NDVI-each containing 2200 images with dimensions of 512 × 512 pixels. These images were collected from various global locations using random geographic coordinates and strict criteria for cloud cover, snow presence, and water percentage, ensuring high-quality and diverse data.

Blood DNA Methylation Signature for Incident Dementia: Evidence from Longitudinal Cohorts.

Introduction: Distinguishing between molecular changes that precede dementia onset and those resulting from the disease is challenging with cross-sectional studies.

Methods: We studied blood DNA methylation (DNAm) differences and incident dementia in two large longitudinal cohorts: the Offspring cohort of the Framingham Heart Study (FHS) and the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. We analyzed blood DNAm samples from over 1,000 cognitively unimpaired subjects.