Comparing Articaine brands: A randomized non-inferiority controlled trial.

Introduction: The substitution of reference drugs for similar, new or existing drugs in the market is a dilemma present in daily dental procedures. In order to decide whether or not to adopt a new drug in relation to the reference, a clinical trial can provide the necessary evidence.

Methods: A total of 179 healthy volunteers (18-25 years) requiring extraction of mandibular third molars completed the study.