Application of Raman hyperspectral imaging for bio-fluid spots segmentation and characterization on cotton supports.

Forensic analysis of biological traces based on advanced approaches like DNA fingerprinting, serology and toxicology plays a crucial role in suspect identification and event reconstruction. In the last decades, non-destructive spectroscopic and imaging techniques have often permitted to gather preliminary information on the presence of biological fluids in specific locations of a crime scene. This study combines Raman hyperspectral imaging with chemometrics to characterize biological stains on cotton supports.

d-[5-C]-Glutamine Positron Emission Tomography Imaging for Diagnosis and Therapeutic Monitoring of Orthopedic Implant Infections.

Orthopedic implant infections (OIIs) present diagnostic and therapeutic challenges, owing to the lack of methods to distinguish between active infection and sterile inflammation. To address this unmet need, d-amino-acid-based radiotracers with unique metabolic profiles in microorganisms have emerged as a novel class of infection-specific imaging agents. Given the pivotal role of d-glutamine in bacterial biofilm formation and virulence, herein, we explored the potential of positron emission tomography (PET) imaging with d-[5-C]-Glutamine (d-[5-C]-Gln) for early detection and treatment monitoring of OIIs.

Outpatient Parenteral Antimicrobial Therapy in a Safety Net Hospital: Opportunities for Improvement.

Background: Outpatient parenteral antimicrobial therapy (OPAT) is a safe and cost-effective transitional care approach administered via different delivery models. No standards exist for appropriate OPAT program staffing. We examined outcomes of patients receiving OPAT via different care models to identify strategies to improve safety while reducing health care overuse.

A tutorial on potentiometric data processing. Analysis of software for optimization of protonation constants.

Defining the distribution of the chemical species in a multicomponent system is a task of great importance with applications in many fields. To clarify the identity and the abundance of the species that can be formed by the interaction of the components of a solution, it is fundamental to know the formation constants of those species. The determination of equilibrium constants is mainly performed through the analysis of experimental data obtained by different instrumental techniques.