Publications by authors named "L Cassagnes"
To determine the prevalence of functional, respiratory and renal impairments and of post-intensive-care-syndrome (PICS) among patients who had attended a post-ICU multidisciplinary consultation (post-ICU-MC) around 3 months after ICU discharge, we performed a retrospective, monocentric observational study, at Clermont Ferrand University hospital, France. We included patients who had attended a post-ICU-MC. Their characteristics during ICU stay and at the post-ICU-MC were collected.
View Article and Find Full Text PDFIntroduction: The COVID-19 pandemic has been associated with significant variability in acute kidney injury (AKI) incidence, leading to concerns regarding patient heterogeneity. The study's primary objective was a cluster analysis, to identify homogeneous subgroups of patients (clusters) using baseline characteristics, including inflammatory biomarkers. The secondary objectives were the comparisons of MAKE-90 and mortality between the different clusters at three months.
View Article and Find Full Text PDFChemotherapy effects on mitochondrial function in adipose tissue in oesophageal and gastroesophageal junction adenocarcinomas with or without associated cachexia: protocol for a prospective, comparative observational study (ChiFMeOE).
BMJ Open
October 2024
Article Synopsis
- Cachexia, a condition often linked to digestive cancers like oesophagogastric cancer, is believed to be influenced by mitochondrial activity in adipose tissue, particularly in response to chemotherapy.
- The ChiFMeOE study aims to investigate how cachexia affects energy metabolism in fat cells and how these changes respond to chemotherapy in patients undergoing treatment for specific types of cancer.
- This study will include 60 patients and focus on collecting tissue biopsies and assessing mitochondrial function, while ensuring ethical standards are maintained through proper consent and oversight.
Article Synopsis
- Syphilis is a sexually transmitted infection that can progress through multiple stages, with tertiary syphilis potentially affecting the cardiovascular system 10 to 40 years after the initial infection.
- The case highlighted involves a 49-year-old man who experienced temporary vision loss, leading to hospital admission where imaging showed severe cardiovascular complications like aortitis and stroke.
- A postmortem examination confirmed the diagnosis of tertiary syphilis, revealing syphilitic aortitis as the underlying cause of the patient's severe health issues.
Background: CT-scan and inflammatory and coagulation biomarkers could help in prognostication of COVID-19 in patients on ICU admission.
Objective: The objectives of this study were to measure the prognostic value of the extent of lung parenchymal lesions on computed tomography (CT) and of several coagulation and inflammatory biomarkers, and to explore the characteristics of the patients depending on the extent of lung parenchymal lesions.
Design: Retrospective monocentric observational study achieved on a dataset collected prospectively.