Publications by authors named "L Carolis"
Article Synopsis
- Autonomic failure significantly affects the quality of life for individuals with advanced Parkinson's disease (PD), prompting the need to evaluate the impact of Levodopa/carbidopa intestinal gel (LCIG) on autonomic dysfunction.
- A systematic review identified 16 studies involving 1361 PD patients, assessing the effects of LCIG on gastrointestinal, urinary, and cardiovascular symptoms over time, with most studies reporting improvements or stability.
- While many patients benefited from LCIG, some experienced worsening autonomic symptoms and there were reports of mild adverse events related to the treatment, highlighting the need for further targeted research in this area.
Distinct outcomes of BRAF inhibition in BRAF-mutated hairy cell neoplasms with wild-type or mutant TP53, and alternative strategies to overcome mutant TP53.
View Article and Find Full Text PDFDaily steps could be a valuable indicator of real-world ambulation in Parkinson's disease (PD). Nonetheless, no study to date has investigated the minimum number of days required to reliably estimate the average daily steps through commercial smartwatches in people with PD. Fifty-six patients were monitored through a commercial smartwatch for 5 consecutive days.
View Article and Find Full Text PDFBackground: Cognitive impairment of intellectual developmental disorders (IDD) is determined by several different combinations of specific cognitive alterations. People with IDD present a rate of mental health problems that is up to 4 times higher than that of the general population. Despite this, the relationship between specific cognitive dysfunctions and co-occurring mental disorders has not been adequately studied.
View Article and Find Full Text PDFArticle Synopsis
- - Mitochondrial alterations are frequently observed in muscle biopsies of sporadic inclusion body myositis (s-IBM) and polymyositis with mitochondrial pathology, but they are less common in dermatomyositis (DM), where their impact on treatment outcomes remains unclear.
- - A case study is presented involving a 77-year-old woman with anti-Mi-2 positive dermatomyositis who exhibited severe muscle weakness and significant mitochondrial abnormalities, showing poor response to standard therapies but some improvement with anti-JAK treatment.
- - The findings suggest that mitochondrial dysfunction could indicate greater disease severity in DM, leading to worse treatment responses, and supports the exploration of JAK-inhibitors as a potential option for cases with mitochondrial abnormalities