Extensive subcutaneous emphysema treated with subcutaneous angiocatheters.

Subcutaneous emphysema (SCE) seen in the emergency department is usually the result of traumatic chest injuries, surgical complications, or invasive airway procedures. SCE is usually a self-limiting phenomenon involving the chest wall and neck, though may progress to involve the deeper tissues leading to respiratory and cardiovascular compromise. Emergent intervention is indicated in such cases of extensive SCE, though the ideal approach to its management is not known.

SVEP1 influences monocyte to macrophage differentiation via integrin α4β1/α9β1 and Rho/Rac signalling.

Background: The large extracellular matrix protein SVEP1 mediates cell adhesion via integrin α9β1. Recent studies have identified an association between a missense variant in SVEP1 and increased risk of coronary artery disease (CAD) in humans and in mice Svep1 deficiency alters the development of atherosclerotic plaques. However how SVEP1 functionally contributes to CAD pathogenesis is not fully understood.

The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins α9β1 and α4β1.

Background And Purpose: Vascular tone is regulated by the relative contractile state of vascular smooth muscle cells (VSMCs). Several integrins directly modulate VSMC contraction by regulating calcium influx through L-type voltage-gated Ca channels (VGCCs). Genetic variants in ITGA9, which encodes the α9 subunit of integrin α9β1, and SVEP1, a ligand for integrin α9β1, associate with elevated blood pressure; however, neither SVEP1 nor integrin α9β1 has reported roles in vasoregulation.