Publications by authors named "L Caponecchia"

Article Synopsis
  • - A study during the COVID-19 pandemic focused on why men experienced more severe disease outcomes, specifically examining the androgen receptor gene and hormone levels in male patients.
  • - Researchers analyzed 142 male patients who had recovered from COVID-19, discovering that an increase in CAG repeats in the androgen receptor gene correlated with worse disease severity and that testosterone levels were notably lower in more severe cases.
  • - The findings suggest that reduced androgen signaling in men, indicated by higher CAG repeats and lower testosterone, may increase their risk of experiencing severe symptoms due to heightened inflammatory responses, potentially leading to multi-organ damage.
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Purpose: While SARS-CoV-2 infection appears not to be clinically evident in the testes, indirect inflammatory effects and fever may impair testicular function. To date, few long-term data of semen parameters impairment after recovery and comprehensive andrological evaluation of recovered patients has been published. The purpose of this study was to investigate whether SARS-CoV-2 infection affect male reproductive health.

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Objectives: Evaluating the relationship between circulating metabolic biomarkers and semen parameters in obese, overweight and normal-weight patients.

Methods: Patients were recruited at the "Andrology and Pathophysiology of Reproduction Unit", in Santa Maria Goretti Hospital. Divided into three groups were 98 participants (obese, overweight and normal-weight patients) according to BMI and were analyzed for three adipokines and six hormone peptides in blood serum and seminal plasma using Luminex assay.

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Purpose: The recent pandemic of severe acute respiratory syndrome (SARS) due to coronavirus (CoV) 2 (SARS-CoV-2) has raised several concerns in reproductive medicine. The aim of this review is to summarize available evidence providing an official position statement of the Italian Society of Andrology and Sexual Medicine (SIAMS) METHODS: A comprehensive Pubmed, Web of Science, Embase, Medline and Cochrane library search was performed. Due to the limited evidence and the lack of studies, it was not possible to formulate recommendations according to the Oxford 2011 Levels of Evidence criteria.

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Vitamin E is a potent antioxidant that has been considered involved in fertility, but studies have mostly focused on α-tocopherol. Our study aimed at measuring, by an isotope dilution gas chromatography-mass spectrometry method, α- and γ-tocopherol concentration in human semen in a large and well-characterised population (134 men with different semen parameters and in varicocele patients), as well as their potential role in male fertility. We carried out freeze/thaw experiments in 15 samples with the two isomers in the cryoprotective medium.

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