Publications by authors named "L Caplan"
Objective: To describe intraoperative cardiac arrest in patients undergoing congenital heart surgery.
Methods: The Society of Thoracic Surgeons Congenital Heart Surgery Database was queried. Predictors of intraoperative cardiac arrest were assessed using univariate and multivariable analyses.
Article Synopsis
- - The study analyzed 3847 patients who suffered from a transient ischemic attack or minor ischemic stroke, focusing on those without traditional risk factors (like hypertension and diabetes) to compare their outcomes with those who did have risk factors.
- - After one year, the risk of major cardiovascular events (MACE) was similar between the two groups, but after five years, those without traditional risk factors had a significantly lower risk of MACE (7.9% vs 13.9%).
- - In patients without traditional risk factors, arterial stenosis was identified as a critical predictor for MACE, indicating that while their long-term risk was lower, they were not entirely without risk.
Congenital cardiac anesthesiologists practice in a unique environment with high risk for morbidity and mortality. Quality metrics can be used to focus clinical initiatives on evidence-based care and provide a target for local quality improvement measures. However, there has been no comprehensive review on appropriate quality metrics for congenital cardiac anesthesia to date.
View Article and Find Full Text PDFTuft cells are a rare epithelial cell type that play important roles in sensing and responding to luminal antigens. A defining morphological feature of this lineage is the actin-rich apical "tuft," which contains large fingerlike protrusions. However, details of the cytoskeletal ultrastructure underpinning the tuft, the molecules involved in building this structure, or how it supports tuft cell biology remain unclear.
View Article and Find Full Text PDFObjectives: The objectives are to assess smoking abstinence and its effects on vascular risk and to report tobacco-cessation counselling and pharmacotherapy use in patients who had a recent minor stroke or transient ischaemic attack (TIA).
Design And Setting: The TIA registry.org project is a prospective, observational registry of patients with TIA and minor stroke that occurred in the previous 7 days with a 5-year follow-up, involving 61 sites with stroke specialists in 21 countries (Europe, Asia, Latin America and Middle East).