Publications by authors named "L Canclini"
Exposure to ultraviolet radiation from sunlight induces oxidative DNA lesions and bipyrimidine photoproducts that can lead to photo-aging and skin carcinogenesis. CPD-photolyases are flavoproteins that repair cyclobutane pyrimidine dimers using blue light as an energy source. In the present work, we evaluated the photo-repair effect of the recombinant CPD-photolyase PhrAHym from the Antarctic bacterium Hymenobacter sp.
View Article and Find Full Text PDFAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive death of motor neurons and muscle atrophy, with defective neuron-glia interplay and emergence of aberrant glial phenotypes having a role in disease pathology. Here, we have studied if the pigment violacein with several reported protective/antiproliferative properties may control highly neurotoxic astrocytes (AbAs) obtained from spinal cord cultures of symptomatic hSOD1G93A rats, and if it could be neuroprotective in this ALS experimental model. At concentrations lower than those reported as protective, violacein selectively killed aberrant astrocytes.
View Article and Find Full Text PDFCell migration is a process that underlies the development and maintenance of multicellular organisms, with profound implications in various pathologies. The study of cell migration is fundamental in various fields of basic biology and pharmaceutical development. Wound healing assay is an indirect way to assess cell migration.
View Article and Find Full Text PDFProprotein convertase subtilisin/kexin type-9 (PCSK9) is key regulator of low-density lipoprotein (LDL) metabolism. A significant proportion of PCSK9 is believed to be associated with LDL in plasma as it circulates, although this finding is still a matter of debate. The purpose of this study was to establish an experimental method to investigate the presence of such an interaction in the bloodstream.
View Article and Find Full Text PDFArticle Synopsis
- Charcot-Marie-Tooth (CMT) type 1 is a common hereditary nerve disease, with 70% of cases linked to pmp22 mutations.
- Trembler-J (TrJ/+) mice, a model for CMT1E, displayed anxiety-like behaviors compared to normal mice, including head shaking and increased grooming.
- Changes in pmp22 expression and aggregated PMP22 in the hippocampus suggest a connection between this peripheral neuropathy and central nervous system anxiety behaviors in the TrJ/+ mice.