Publications by authors named "L Calzadilla-Bertot"
Background And Aim: Prognosis in autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) has historically been poor. This multicenter retrospective cohort study investigated the natural history and assessed the predictors of outcomes in patients with AIH, PBC, and PSC.
Methods: AIH, PBC, and PSC patients were identified from the state-wide Hepascore and Clinical Outcome cohort.
Article Synopsis
- The study aimed to assess survival rates in patients with autoimmune liver disease overlap syndromes (AILDOS) compared to those with single autoimmune liver diseases, specifically focusing on liver-related mortality.
- 22 patients were studied over a median of 3.1 years, showing a 57% survival rate free from liver-related mortality at five years, with differences observed between types of AILDOS.
- The liver outcome score (LOS) was a significant predictor of mortality for those with AIH-PBC, while the commonly used MELD score and others were not effective in predicting outcomes in either group.
Background And Aims: Management of NAFLD involves noninvasive prediction of fibrosis, which is a surrogate for patient outcomes. We aimed to develop and validate a model predictive of liver-related events (LREs) of decompensation and/or HCC and compare its accuracy with fibrosis models.
Approach And Results: Patients with NAFLD from Australia and Spain who were followed for up to 28 years formed derivation (n = 584) and validation (n = 477) cohorts.
Editorial: targeting liver biopsy in NAFLD - the need to expand non-invasive tools.
Aliment Pharmacol Ther
January 2022