Publications by authors named "L Cafaro"
Article Synopsis
- - Atypical chronic lymphocytic leukemia (CLL) is diagnosed based on shape and structure, but deviations from the usual immune profile indicate a need to look for atypical cases.
- - In a study comparing atypical and typical CLL cases, atypical presentations showed distinct immune marker expressions, including higher CD20 and unmutated IgVH rates, and were associated with more advanced disease stages.
- - While morphological features seem to provide better insights into patient prognosis, the effectiveness of using both morphology and immunophenotype in guiding treatment decisions remains uncertain and requires additional research.
Tau tubulin kinase-1 (TTBK1), a neuron-specific tau kinase, is highly expressed in the entorhinal cortex and hippocampal regions, where early tau pathology evolves in Alzheimer's disease (AD). The protein expression level of TTBK1 is elevated in the cortex brain tissues with AD patients compared to the control subjects. We therefore hypothesized that antisense oligonucleotide (ASO) based targeting Ttbk1 could prevent the accumulation of phosphorylated tau, thereby delaying the development of tau pathology in AD.
View Article and Find Full Text PDFStudy Question: Is Ongoing Pregnancy Rate (OPR) operator-dependent, and can experience improve embryo transfer efficiency?
Summary Answer: OPR is influenced by the operators who perform the embryo transfer (ET), and experience does not assure proficiency for everyone.
What Is Known Already: ET remains the critical step in assisted reproduction. Although many other factors such as embryo quality and uterine receptivity impact embryo implantation, the proper ET technique is clearly an operator-dependent variable and as such it should be objectively standardized.
The need for treating subclinical hypothyroidism (SCH) in women undergoing assisted reproduction technology (ART) is under debate. Moreover, it is known that controlled ovarian hyperstimulation (COH) protocols may impair the thyroidal axis. Therefore, we evaluated if levothyroxine (L-T4) supplementation in SCH women before undergoing ART positively affects the main reproductive outcomes.
View Article and Find Full Text PDFPurpose: To analyse the impact of female characteristics on assisted reproductive technology outcome among male haematological cancer survivors.
Methods: A retrospective analysis of 93 haematological cancer survivors attending our tertiary referral fertility centre between June 1998 and June 2017 for achieving fatherhood with assisted reproductive technology treatments.
Results: A progressive increase in the median female age was observed during the study period (32.