Longitudinal associations of carotid artery stiffness with progression of cerebrovascular disease, incident dementia and cognitive decline in older adults.

Background: Carotid artery stiffness is associated with cerebrovascular disease (CeVD) and cognitive impairment, but evidence for its longitudinal effects on progression of CeVD and cognitive decline are limited.

Objectives: To evaluate the longitudinal associations of carotid artery stiffness with CeVD progression, incident dementia, and cognitive decline.

Design: Longitudinal analyses from a memory-clinic cohort with a follow-up of 2 years.

Global containment policy duration and long-term epidemic progression: a target trial emulation using COVID-19 data from 2020 to 2022.

Objectives: Global countries often apply containment policies (CPs) to combat infectious disease surges. Whether countries with longer cumulative duration of CPs are associated with slower long-term epidemic progression necessitates a thorough evaluation.

Methods: We collected CP and COVID-19 data of 185 territories during 2020-2022, with a total of 23 CPs.

Development and validation of a machine learning model for predicting intrapartum fever using pre-labor analgesia clinical indicators: a multicenter retrospective study.

Background: Labor anesthesia is commonly used for pain relief during labor, but it can increase the risk of intrapartum fever. Currently, there are no reliable tools to predict which parturients might develop fever before labor anesthesia. The prediction model we developed aims to predict the incidence of intrapartum fever before labor analgesia.

Plain Language Summary of Publication: Design of the Phase 3 AZALEA Trial of Nipocalimab in Severe Hemolytic Disease of the Fetus and Newborn.

This article is a plain language summary of publication (PLSP) of the following article: Design of a phase 3, global, multicenter, randomized, placebo-controlled, double-blind study of nipocalimab in pregnancies at risk for severe hemolytic disease of the fetus and newborn by Komatsu et al published in on September 17, 2024 (doi:10.1055/a-2404-8089). This PLSP describes the design of the phase 3 AZALEA clinical trial in pregnant participants at risk for developing severe hemolytic disease of the fetus and newborn (HDFN).

Paternal age and neonatal outcomes: a population-based cohort study.

Study Question: Is paternal age associated with neonatal outcomes?

Summary Answer: Paternal age is independently associated with preterm birth (PTB) and caesarean section.

What Is Known Already: Advanced maternal age has long been recognized as a major risk factor for adverse neonatal outcomes. However, the association between paternal age and neonatal outcomes are not well established, yet it is biologically plausible that an increasing number of genetic and epigenetic sperm abnormalities in older males may contribute to adverse neonatal outcomes.