Publications by authors named "L C Zeferino"
Prognosis and cardiotoxicity associated to adjuvant trastuzumab for breast cancer: real world study in a public health system.
Rev Bras Ginecol Obstet
December 2024
Objective: To analyze the prognosis of patients with breast cancer who developed trastuzumab-induced cardiotoxicity and to analyze factors associated with and resulting from cardiotoxicity.
Methods: This was a retrospective cohort study that included 255 HER2-positive breast cancer patients who received adjuvant trastuzumab therapy. The inclusion criteria were a diagnosis of HER2-positive breast cancer and adjuvant trastuzumab therapy; disease stage I-III; <70 years; and a baseline echocardiogram showing a left ventricular ejection fraction (LVEF) ≥ 55%.
Cervical cancer screening in Brazil is opportunistic, based on cytology and offered for women aged 25-64 years, with low coverage (30%) and 70% of cancer diagnoses done in advanced stages, without impact on mortality. The current study reports 5-year first-round results of a population-based DNA-HPV testing screening program in a Brazilian city, which intended to be a model for transition to a more efficient program. Program flowchart is simple and current, indicating repetition of a negative test after five years.
View Article and Find Full Text PDFCancer stem cells (CSC), a small population of neoplastic cells, are associated with worse prognosis. The aim of this study was to evaluate the expression of ALDH1, CD117, CD133 and OCT4; potential markers of CSC; and their associations with the prognosis of women diagnosed with cervical cancer. This retrospective cohort study included 126 women diagnosed with cervical cancer whose biopsies were analyzed by immunohistochemistry.
View Article and Find Full Text PDFArticle Synopsis
- Indigenous women in Brazil are more vulnerable to cervical cancer and have higher rates of Low-grade Squamous Intraepithelial Lesions (LSIL) compared to non-Indigenous women, particularly in certain age groups.
- The study analyzed cytological results from 3,231 tests on Indigenous women and 698,415 tests on non-Indigenous women, revealing that while HSIL+ rates were low in younger women, there were notable peaks in Indigenous women aged 25 to 34.
- Unlike non-Indigenous women, who showed protective effects from screening, Indigenous women did not benefit from screening tests, highlighting the urgent need for targeted public health strategies.
Article Synopsis
- The study investigated the relationship between the Index of Social Responsibility (ISR) and the diagnosis of cervical cancer in 645 municipalities in Sao Paulo, Brazil, focusing on factors like stage, age, and morphology.
- Data from 9,095 women aged 30 and older was analyzed, revealing that higher ISR levels correlated with an increased proportion of early-stage diagnoses and a greater likelihood of younger women being diagnosed in wealthier areas.
- The findings suggest that the ISR is a valuable health indicator for identifying social determinants affecting cervical cancer diagnosis, emphasizing that better social conditions lead to a higher diagnosis rate of stage I cervical cancer.