Activatable Photosensitizer Prodrug for Self-Amplified Immune Therapy via Pyroptosis.

Immunotherapy is a promising cancer treatment, but its application is hindered by tumors' low immunogenicity and the difficulty of immune cell infiltration. Here, to address above issues and achieve targeted tumor treatment, we designed the first activated small molecule photosensitizer immune-prodrug HDIM based on pyroptosis, and proposed a self-amplified immune therapy strategy (SITS) for enhanced tumor therapy. HDIMcan be specifically activated by the tumor hypoxiaand then simultaneously initiate immuno-therapy and photodynamic therapy (PDT)-induced pyroptosis with NIR laser irradiation.

Tinagl1 restores tamoxifen sensitivity and blocks fibronectin-induced EMT by simultaneously blocking the EGFR and β1-integrin/FAK signaling pathways in tamoxifen-resistant breast cancer cells.

Tamoxifen (TAM) is employed to treat premenopausal ER-positive breast cancer patients, but TAM resistance is the main reason affecting its efficacy. Thus, addressing TAM resistance is crucial for improving therapeutic outcomes. This study explored the potential role of Tinagl1, a secreted extracellular matrix protein, whose expression is compromised in TAM-resistant MCF-7 breast cancer cells (MCF-7R).

DBU-catalyzed annulation strategy for modular assembly of 2,3-difunctionalized dihydrobenzofurans.

An organocatalytic approach for the construction of 2,3-dihydrobenzofuran scaffold through a formal [4 + 1] annulation of 2-(2-nitrovinyl)phenols and α-bromoacetophenones in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed.

SDES-YOLO: A high-precision and lightweight model for fall detection in complex environments.

Falling is an emergency situation that can result in serious injury or even death, especially in the absence of immediate assistance. Therefore, developing a model that can accurately and promptly detect falls is crucial for enhancing quality of life and safety. In the field of object detection, while YOLOv8 has recently made notable strides in detection accuracy and speed, it still faces challenges in detecting falls due to variations in lighting, occlusions, and complex human postures.

Disinfection efficacy of peroxyacetic acid against bacterial spores.

Peracetic acid (PAA) is an emerging disinfectant known to be highly effective against various microorganisms. However, the capability of PAA to eliminate spores under different conditions and its application in liquid and gaseous forms remain unclear. Here, we aimed to develop a stabilized single-composite PAA and evaluate its disinfection efficacy in both liquid and gaseous form against suspended or surface-coated spores under varying temperature and humidity conditions.