Publications by authors named "L C Wynne"
Background: Stigma significantly impacts individuals with Parkinson's disease (PD) and their caregivers, exacerbating social isolation, psychological distress, and reducing quality of life (QoL). Although considerable research has been conducted on PD's clinical aspects, the social and emotional challenges, like stigma, remain underexplored. Addressing stigma is crucial for enhancing well-being, fostering inclusivity and improving access to care and support.
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- The BYPASS-CTCA trial found that using computed tomography cardiac angiography (CTCA) prior to invasive coronary angiography (ICA) in patients with previous bypass surgery reduces procedure time and the risk of kidney injury, improving patient satisfaction.
- In this study, 688 patients were divided into two groups: one receiving CTCA before ICA and the other receiving ICA alone, with follow-up averaging 3 years.
- Results showed that although benefits like being angina-free and improved quality of life were seen at 3 months, long-term outcomes showed CTCA/ICA patients had lower imaging resource use and fewer major adverse cardiac events compared to those who only had ICA.
Perioperative Point-of-Care Ultrasound (POCUS) for Anaesthetists: Is It Time to Introduce Formal Training?
Br J Hosp Med (Lond)
October 2024
This article reviews point-of-care ultrasound (POCUS) in the perioperative period. Ultrasound-guided techniques for regional anaesthesia and vascular access have been well-established in anaesthesia for many years. However, integration of whole-body POCUS into UK anaesthetic practice remains limited.
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- The study focuses on contrast-induced nephropathy (CIN), a type of kidney injury that can happen during heart procedures, and looks at how inorganic nitrate might help prevent it.
- In the trial called NITRATE-CIN, high-risk patients were given either potassium nitrate or a placebo for 5 days to see if it could lower the chances of developing CIN.
- Results showed that patients taking inorganic nitrate had a much lower rate of CIN (9.1%) compared to those on placebo (30.5%), and it also helped improve kidney function and reduce heart problems.
Background: Computed tomography cardiac angiography (CTCA) is recommended for the evaluation of patients with prior coronary artery bypass graft (CABG) surgery. The BYPASS-CTCA study demonstrated that CTCA prior to invasive coronary angiography (ICA) in CABG patients leads to significant reductions in procedure time and contrast-induced nephropathy (CIN), alongside improved patient satisfaction. However, whether CTCA information was used to facilitate selective graft cannulation at ICA was not protocol mandated.
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