Publications by authors named "L C Vanbrabant"
Multiple sclerosis (MS) is a neurodegenerative, autoimmune disease that is still incurable. Nowadays, a variety of new drugs are being developed to prevent excessive inflammation and halt neurodegeneration. Among these are the inhibitors of Bruton's tyrosine kinase (BTK).
View Article and Find Full Text PDFSeveral inflammatory diseases are characterized by a disruption in the equilibrium between the host and its microbiome. Due to the increase in resistance, the use of antibiotics for the widespread, nonspecific killing of microorganisms is at risk. Pro-microbial approaches focused on stimulating or introducing beneficial species antagonistic toward pathobionts may be a viable alternative for restoring the host-microbiome equilibrium.
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- Interferon-γ-inducible protein of 10 kDa (IP-10/CXCL10) functions as a chemokine that attracts activated T and NK cells by binding to its receptor CXCR3, although its natural posttranslational modifications, especially at the C-terminus, have not been fully understood.
- Research involved analyzing synovial fluid from rheumatoid arthritis patients to compare the levels of natural and intact CXCL10 using mass spectrometry and various biological assays to assess its effects on cell behavior.
- Findings revealed that natural CXCL10 was more prevalent and had reduced binding affinity for glycosaminoglycans and weaker signaling capabilities, indicating its diminished effectiveness in promoting immune cell migration and activation
Frequent Allergic Sensitization to Farmed Edible Insects in Exposed Employees.
J Allergy Clin Immunol Pract
December 2023
Article Synopsis
- * Testing revealed that a majority had positive reactions for insect allergens, and many displayed bronchial hyperreactivity or had co-sensitization with house dust mites.
- * The findings highlight the need for preventive measures and ongoing health surveillance in the growing insect production industry to protect employee health.
Article Synopsis
- Primary ciliary dyskinesia (PCD) is a genetic disorder that causes repeated airway infections, and there are currently no specific treatments available for it.
- This study analyzed neutrophils (a type of immune cell) from both the sputum of PCD patients and their blood, finding that sputum neutrophils were highly activated but were unresponsive to normal stimuli.
- The research suggests that dysfunctional neutrophils in PCD may worsen inflammation in the airways, and further studies should explore anti-inflammatory treatments and ways to enhance the clearance of dead cells.