Effectiveness of a Nutrition Counseling Intervention on Food Consumption, According to the Degree of Processing: A Community-Based Non-Randomized Trial of Quilombola Communities in South Brazil.

Objectives: To evaluate the effectiveness of a nutrition counseling intervention on food consumption according to the Nova classification that reflects levels of food processing.

Methods: Controlled community trial was conducted in quilombola communities in the South of Brazil. Four communities were allocated to the control group (CG) and the intervention group (IG), two communities comprised each group.

GLP-1 receptor agonists for Parkinson's disease: An updated meta-analysis.

Introduction: Treatments for Parkinson's disease (PD) focus on symptom reduction through dopaminergic therapies, without clear evidence of disease-modifying effects. Glucagon-like peptide-1 (GLP-1) receptor agonists may reduce neuroinflammation by decreasing microglia activation in PD. Clinical trials suggest these agents have disease-modifying potential in PD.

Co-occurring mutations identify prognostic subgroups of microsatellite stable colorectal cancer.

Background: Co-occurring mutations in pairs of genes can pinpoint clinically relevant subgroups of cancer. Most colorectal cancers (CRCs) are microsatellite stable (MSS) and have few frequent mutations. Large patient cohorts and broad genomic coverage are needed for comprehensive co-mutation profiling.

Elucidating the conformational behavior and membrane-destabilizing capability of the antimicrobial peptide ecPis-4s.

Here we present studies of the structure and membrane interactions of ecPis-4 s, a new antimicrobial peptide from the piscidin family, which shows a wide-range of potential biotechnological applications. In order to understand the mode of action ecPis-4 s, the peptide was chemically synthesized and structural investigations in the presence of anionic POPC:POPG (3:1, mol:mol) membrane and SDS micelles were performed. CD spectroscopy demonstrated that ecPis-4 s has a high content of helical structure in both membrane mimetic media, which is in line with solution NMR spectroscopy that revealed an amphipathic helical conformation throughout the entire peptide chain.

Steered Response Power for Sound Source Localization: a tutorial review.

In the last three decades, the Steered Response Power (SRP) method has been widely used for the task of Sound Source Localization (SSL), due to its satisfactory localization performance on moderately reverberant and noisy scenarios. Many works have analysed and extended the original SRP method to reduce its computational cost, to allow it to locate multiple sources, or to improve its performance in adverse environments. In this work, we review over 200 papers on the SRP method and its variants, with emphasis on the SRP-PHAT method.