Publications by authors named "L C Ravin"
Article Synopsis
- Post-thrombotic syndrome (PTS) is a frequent complication following deep vein thrombosis (DVT), affecting 20-50% of patients and leading to a lower quality of life, with limited effective clinical predictors available for assessing PTS risk.
- A pilot study investigated the neutrophil-to-lymphocyte ratio (NLR), an indicator of systemic inflammation, as a potential predictive biomarker for PTS in patients diagnosed with iliofemoral DVT.
- The study found that an NLR cut-off of 7.71 could significantly predict PTS, with 36.44% of patients experiencing the syndrome, suggesting that NLR could be a useful tool in evaluating PTS risk alongside other clinical markers.
Since double-stranded RNA (dsRNA) is effective for silencing a wide variety of genes, all genes are typically considered equivalent targets for such RNA interference (RNAi). Yet, loss of some regulators of RNAi in the nematode can selectively impair the silencing of some genes. Here, we show that such selective requirements can be explained by an intersecting network of regulators acting on genes with differences in their RNA metabolism.
View Article and Find Full Text PDFSince double-stranded RNA (dsRNA) is effective for silencing a wide variety of genes, all genes are typically considered equivalent targets for such RNA interference (RNAi). Yet, loss of some regulators of RNAi in the nematode can selectively impair the silencing of some genes. Here we show that such selective requirements can be explained by an intersecting network of regulators acting on genes with differences in their RNA metabolism.
View Article and Find Full Text PDF