Publications by authors named "L C Pinilla"
Introduction: Understanding the diverse pathogenetic pathways in obstructive sleep apnea (OSA) is crucial for improving outcomes. microRNA (miRNA) profiling is a promising strategy for elucidating these mechanisms.
Objective: To characterize the pathogenetic pathways linked to OSA through the integration of miRNA profiles, machine learning (ML) and bioinformatics.
Article Synopsis
- Obstructive sleep apnea (OSA) significantly impacts cardiovascular event recurrence in patients with acute coronary syndrome (ACS), particularly in those without prior cardiovascular disease.
- The study identified two groups based on the severity of OSA and utilized proteomics to analyze plasma proteins, revealing 24 differentially expressed proteins associated with OSA severity.
- Bioinformatic analysis suggested that these proteins are involved in key molecular pathways related to immune function, cell signaling, and inflammation, linking OSA to adverse cardiovascular outcomes.
Article Synopsis
- Polycystic ovary syndrome (PCOS) is a complex condition characterized by irregular ovulation, high levels of androgens, and the presence of polycystic ovaries, often leading to metabolic issues like obesity and insulin resistance.
- Current treatments mainly address symptoms but are often ineffective for the underlying metabolic and reproductive problems.
- Research shows that a GLP1-based treatment, specifically GLP1/Estrogen (GLP1/E), is more effective in managing PCOS-related metabolic complications and improving ovulation than other multi-agonists and metformin, suggesting a more personalized approach to treatment.
Introduction: Among all patients with hypertension, those with resistant hypertension (RH) have the highest rates of subclinical organ damage (SOD). The prevalence of obstructive sleep apnea (OSA) is high in RH patients, and it could contribute to SOD. We aimed to investigate how OSA and its treatment are related to SOD in a large cohort of RH patients.
View Article and Find Full Text PDFPredictors and markers of the cardiovascular impact of obstructive sleep apnoea.
Curr Opin Pulm Med
November 2024
Purpose Of Review: Obstructive sleep apnoea (OSA) is the most common form of sleep-disordered breathing and has been linked to cardiovascular health. However, some of the findings supporting this are controversial. These discrepancies might be a result of heterogeneity among OSA patients, and thus, additional information would be required to better stratify OSA patients according to cardiovascular risk.
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