Targeting P4HA1 promotes CD8 T cell progenitor expansion toward immune memory and systemic anti-tumor immunity.

Successful immunotherapy relies on both intratumoral and systemic immunity, which is yet to be achieved for most patients with cancer. Here, we identify P4HA1, encoding prolyl 4-hydroxylase 1, as a crucial regulator of CD8 T cell differentiation strongly upregulated in tumor-draining lymph nodes (TDLNs) and hypoxic tumor microenvironment. P4HA1 accumulates in mitochondria, disrupting the tricarboxylic acid (TCA) cycle through aberrant α-ketoglutarate and succinate metabolism, promoting mitochondria unfitness and exhaustion while suppressing progenitor expansion.

An MRI-Derived Formula for Estimating the Native Joint Line Position in the Presence of Distal Femoral Bone Loss.

Background  In the presence of distal femoral condyle bone loss, estimation and restoration of the joint line (JL) position can be guided by extraarticular bony landmarks with the aid of mathematical formulas that rely on the innate correlations between periarticular measurements. To prevent JL elevation, the formula should incorporate the thickness of distal femoral articular cartilage. The aim of this study was to derive a formula to estimate native JL position.

The Impact of Age in Patients Undergoing Impella-Assisted Percutaneous Coronary Interventions.

Background: Short-term percutaneous mechanical circulatory support (MCS) devices provide hemodynamic support in cardiogenic shock or during high-risk percutaneous coronary intervention (PCI).

Aims: To assess the impact of age on the clinical and angiographic characteristics and in-hospital outcomes of all patients undergoing PCI with the Impella MCS.

Methods: Data on all patients that underwent PCI with an Impella was divided into three groups according to age: < 65, 65 to < 75 years, and ≥ 75 years.

Interactions between antidiabetes medications and heart-brain axis.

Purpose Of Review: The heart - brain axis (HBA) is the physiological interactions between the cardiovascular and nervous systems through autonomic nerves, hormones, and cytokines. Patients diagnosed with diabetes mellitus have an increased risk of the cardiovascular and neurological diseases. However, recent evidence demonstrated that different antidiabetic drugs may delay cognitive impairment and improve cardiovascular outcomes.

Radio frequency-based human activity dataset collected using ESP32 microcontroller in line-of-sight and non-line-of-sight indoor experiment setups.

This study presents the "ESP32 Dataset," a dataset of radio frequency (RF) data intended for human activity detection. This dataset comprises 10 activities carried out by 8 volunteers in three different indoor floor plan experiment setups. Line-of-sight (LOS) scenarios are represented by the first two experiment setups, and non-line-of-sight (NLOS) scenarios are simulated in the third experiment setup.