Publications by authors named "L C Noronha"
To investigate the association of NANOG polymorphisms with oral leukoplakia. In this case-control study, 68 cases of oral leukoplakia, and 21 of normal oral mucosa (control) were submitted to genotyping of tagSNPs polymorphisms: rs877716 and rs10845877 in NANOG, through real-time polymerase chain reaction (PCR). Pearson's chi-squared and Fisher's exact statistical tests were used, with a significance of 5%.
View Article and Find Full Text PDFThis case report presents the management of a 25-year-old woman with refractory hemophagocytic lymphohistiocytosis (HLH) secondary to adult-onset Still's disease. Despite initial treatment with corticosteroids and biologic therapies, including anakinra and tocilizumab, her condition continued to deteriorate, necessitating intensive care unit admission. Following multidisciplinary consultation, ruxolitinib therapy, a Janus kinase (JAK) inhibitor targeting hyperinflammation, was initiated.
View Article and Find Full Text PDFAnalysis of genetic polymorphism and expression of SOX2 in oral leukoplakia: a case-control study.
Oral Surg Oral Med Oral Pathol Oral Radiol
November 2024
Purpose: To investigate the association of SOX2 polymorphisms with oral leukoplakia with dysplasia (OLD) and compare it with the immunohistochemical expression of SOX-2.
Methods: The samples comprised 64 patients with oral leukoplakia and 20 with normal oral mucosa who were subjected to SOX2 polymorphism rs77677339 genotyping by real-time polymerase chain reaction and immunohistochemistry for SOX-2 (basal epithelium expression, suprabasal and total; nuclear area and intensity). Statistical tests included the Chi-square and Fisher's exact tests.
Background: While loneliness is a global public health problem, the literature lacks studies assessing loneliness predictors in low- and middle-income countries. Therefore, we aimed to analyze clinical and lifestyle predictors of loneliness.
Methods: We conducted a 2-year longitudinal study in Brazil based on a snowball sample and online surveys (baseline: May 6 to June 6, 2020).
Article Synopsis
- COVID-19 causes hypercytokinemia, an imbalance of inflammatory cytokines, which complicates treatment, especially in severe cases.
- A study tracked cytokine levels in SARS-CoV-2 patients over time, finding that elevated levels predicted mortality, particularly for IL-4 and IL-1β.
- The research indicates that changes in levels of specific cytokines like IFN-γ and IL-6 are linked to patient outcomes, emphasizing the role of cytokine dynamics in predicting severe COVID-19 results.