Publications by authors named "L C Malacarne"

Article Synopsis
  • The study investigates the antifungal properties of hypericin when nanoencapsulated in P123 copolymer micelles, focusing on its photodynamic therapy (PDT) mechanisms.
  • Key methods include antifungal susceptibility tests to determine minimum fungicidal concentration, time-kill curves, and flow cytometry to analyze the internalization of the nanoencapsulation and the production of reactive oxygen species (ROS).
  • Results indicate that P123-Hyp maintains fungistatic activity for up to 24 hours, with evidence of necrotic cell death and disruption of the fungal plasma membrane through the activation of type II PDT pathways.
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The growing interest in using photodynamic therapy for cancer treatment and antimicrobial applications has prompted the search for different classes of dyes. In general, the protocols of these studies are different, making it difficult to compare their efficiency directly. Here, we apply a controlled protocol to analyze the photophysical properties of Erythrosin B, Eosin Y, and Rose Bengal using a set of optical techniques.

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Staphylococcus aureus is a global challenge to the clinical field and food industry. Therefore, the development of antimicrobial photodynamic therapy (aPDT) has become one of the valuable methods to control this pathogen. The antibacterial activity of photoinactivation by erythrosine (Ery) against S.

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The interaction of localized light with matter generates optical electrostriction within dielectric fluids, leading to a discernible change in the refractive index of the medium according to the excitation's light profile. This optical force holds critical significance in optical manipulation and plays a fundamental role in numerous photonic applications. In this study, we demonstrate the applicability of the pump-probe, photo-induced lensing (PIL) method to investigate optical electrostriction in various dielectric liquids.

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Background: The efficacy of photodynamic therapy (PDT) depends on the combination of light and a photosensitizer for inactivation of microorganisms. However, finding the ideal conditions for the factors involved in this technique is time and cost-consuming. The rotational composite central design (RCCD) is a tool that can be allied with PDT to achieve precise results within a shorter working time.

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