Publications by authors named "L C Kusinski"
Objectives: Gestational diabetes is diagnosed using an oral glucose tolerance test (OGTT), which has limited accuracy, reproducibility and practicality. We assessed the effect of enhanced pre-analytical glucose processing upon glucose concentrations, gestational diabetes diagnosis, health equity and pregnancy outcomes, and if HbA1c was a suitable alternative.
Methods: We recruited pregnant women with ≥1 risk factor to a prospective observational cohort study of pregnancy hyperglycaemia, endocrine causes, lipids, insulin and autoimmunity (OPHELIA), from nine UK centres.
Article Synopsis
- The study assessed the effectiveness of enhanced insulin secretion and sensitivity measurements in diagnosing and managing gestational diabetes mellitus (GDM) among pregnant women at risk.
- A total of 1,308 pregnant women were analyzed using a standard 75 g oral glucose tolerance test (OGTT) and categorized into specific GDM subtypes based on their insulin resistance and insufficiency levels.
- Results showed that many women classified as having GDM exhibited unique characteristics, including a subgroup that was insulin-sensitive but displayed high blood sugar after meals, indicating the need for refined diagnostic criteria.
Background: The increased risk of pregnancy complications in type 1 diabetes is mainly attributed to maternal hyperglycemia. However, it is unclear whether other potentially modifiable factors also contribute to risk in this population.
Purpose: We sought to assess whether high BMI and excessive gestational weight gain (GWG) are associated with perinatal complications in type 1 diabetes.
Article Synopsis
- Gestational diabetes increases the risk of obesity, type 2 diabetes, and cardiovascular diseases, highlighting the need for better nutritional strategies to improve maternal health.
- A study comparing eating behaviors of women with gestational diabetes to men and non-pregnant women found that women with gestational diabetes exhibited lower uncontrolled and emotional eating, but higher cognitive restraint.
- Emotional eating was positively linked to BMI in women with gestational diabetes, suggesting that addressing emotional eating could be key in developing effective nutritional interventions.
Background: Undiagnosed diabetes in pregnancy is associated with stillbirth and perinatal complications, but standard testing for gestational diabetes using the oral glucose tolerance test (OGTT) is impractical and exacerbates healthcare inequalities. There is an urgent need to improve the accuracy, acceptability and accessibility of glucose testing in pregnancy. We qualitatively assessed the feasibility and acceptability of two alternative home-based methods of glucose testing in pregnant women, using continuous glucose monitoring (CGM), with or without a home-based OGTT.
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