Publications by authors named "L C Horn"
Purpose: Patients with KRAS mutant non-small cell lung cancer (NSCLC) have limited therapeutic options. Based on activity of nuclear export inhibition in preclinical models, we evaluated this strategy in previously treated advanced KRAS mutant NSCLC.
Patients And Methods: The primary outcome of this multi-center phase 1/2 dose escalation trial of selinexor plus docetaxel was safety and tolerability.
Background: Relapsed head and neck squamous cell carcinoma (HNSCC) unrelated to HPV infection carries a poor prognosis. Novel approaches are needed to improve the clinical outcome and prolong survival in this patient population which has poor long-term responses to immune checkpoint blockade. This study evaluated the chemokine receptors CXCR1 and CXCR2 as potential novel targets for the treatment of HPV-negative HNSCC.
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- Cutaneous melanoma (CM) and non-melanoma skin cancer (NMSC) rates are increasing in postmenopausal women, but the impact of vitamin A on their risk remains unclear.
- A study of 52,877 White women found no link between total vitamin A intake and melanoma risk; however, higher dietary vitamin A and beta-cryptoxanthin were correlated with an increased risk of NMSC.
- The findings suggest that while vitamin A does not lower CM or NMSC risk, higher dietary intakes may actually increase NMSC risk in this demographic.
Background: Implications of lifelong, perceived discrimination on nutrient intake during the preconception period are unclear.
Objective: The objective was to identify associations between perceived discrimination and consumption of specific nutrients associated with risk of adverse pregnancy outcomes.
Design: This is a secondary data analysis of the prospective Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be cohort.
Article Synopsis
- A study analyzed the link between fruit and vegetable consumption and blood pressure (BP) and body mass index (BMI) by using objective measurements instead of self-reported dietary assessments, which can be unreliable.
- Researchers used advanced techniques to analyze urine samples from participants in the US and UK, identifying specific metabolites associated with fruit and vegetable intake.
- The findings showed that certain metabolites were inversely related to systolic BP and BMI, highlighting that higher fruit and vegetable intake could lead to lower BP and BMI, largely due to citrate levels in urine.