Genotoxicity of putrescine and its effects on gene expression in HepG2 cell line.

Decomposing bodies release necro-leachate, a toxic fluid containing harmful compounds such as biogenic amines. This study investigated the genotoxic effects of the different concentrations (0.5, 1.

Dietary sp. Meal Enhances the Fatty Acid Profile in Pirarucu () Fillets with No Effect on Growth Performance and Health Status.

This study aimed to assess the impact of dietary supplementation with sp. meal, a source of docosahexaenoic acid (DHA), on the growth, hemato-biochemical parameters, and fatty acid composition of juvenile pirarucu (). Two diets were used: a test diet (5%SZ) and a control diet (0 SZ).

Avelumab Maintenance Therapy in Advanced Urothelial Carcinoma: Implications of Timing and Treatment Sequencing.

Background: Platinum-based chemotherapy (PBC) followed by avelumab maintenance is a treatment option for patients with advanced urothelial carcinoma (aUC) patients. However, the optimal treatment sequencing in the era of antibody-drug conjugates (ADCs) is yet to be determined. Recent studies suggest that the timing of immune checkpoint inhibitor (ICI) administration may impact patient outcomes, with a potential benefit from morning infusions.

Role of Octaspline Multielectrode Catheter and Unipolar Reference Location for Premature Ventricular Contraction Ablation.

Background: An accurate local activation time (LAT) map is essential during premature ventricular contraction (PVC) ablation. The aim of this study was to evaluate whether the use of a novel octaspline multielectrode catheter, with and without the use of a catheter-embedded unipolar reference, improves LAT mapping during PVC ablation compared to a pre-existing pentaspline mapping catheter.

Methods: This study prospectively assessed 10 consecutive patients referred for PVC ablation from January to June 2023.

Global epidemiology of acute kidney injury in hospitalised patients with decompensated cirrhosis: the International Club of Ascites GLOBAL AKI prospective, multicentre, cohort study.

Background: Acute kidney injury (AKI) is a serious complication of cirrhosis. A systematic, global characterisation of AKI occurring in patients with cirrhosis is lacking. We therefore aimed to assess global differences in the characteristics, management, and outcomes of AKI in hospitalised patients with cirrhosis.