Publications by authors named "L C Giancarlo"

Trace metal contamination is a widespread issue due to its many natural and anthropogenic sources and known carcinogenic, teratogenic, and reproductive effects. As previous invertebrate trace metal research has primarily focused on model species (Daphnia magna, Chironomidae, etc.), our understanding of effects on non-model invertebrate species remains relatively poor.

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Coal ash (CA) is an industrial waste product that has been shown to contain several neurotoxic constituents such as cadmium, selenium, mercury, lead, and arsenic. Contaminant-laced leachates enter the environment via seepage, runoff, permitted discharge, or accidental spills from CA storage ponds or landfills which may pose a risk to wildlife residing in receiving waterways. In this study, we assessed 1) the presence and concentration of thirteen trace elements (Al, Ca, Mg, Cr, Cd, As, Se, Pb, Cu, Zn, Mn, Fe, B) in surface water and sediment grab samples using ICP-OES, 2) the temporal variability of trace elements using Pb-210 dated sediment core samples, 3) differences in species diversity using environmental DNA (eDNA) analyses, and 4) the presence and concentration of trace metals in banded killifish (Fundulus diaphanus) epaxial muscle tissue collected from waterways surrounding the Possum Point Power Station (Stafford, VA).

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Cervical spondylotic myelopathy (CSM) is a progressively growing pathology to afford by a spinal surgeon due to the aging of the population, associated with better treatment management and the best diagnosis and treatment solutions are greatly discussed. Nowadays that scientific literature is progressively increasing to identify the gold standard in diagnosis and treatment can be very challenging. This is particularly evident in spinal surgery with many different indications not only in different countries but also in the same local reality.

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Coal fly ash is an industrial waste product generated by coal fired powerplants which has been shown to contain elevated concentrations of several toxic trace metals. When stored in landfills or other repositories, these trace metals can enter nearby surface waters via a number of routes including leaching or runoff. Our study examined 1) the presence and concentration of eleven trace elements in a range of lab-created coal ash leachate solutions at neutral pH using ICP-OES, 2) the physiological effects of these leachate solutions on a freshwater gastropod (Planorbella duryi), and 3) the ability of these trace metals to bioaccumulate in the tissues of exposed individuals.

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In the last ten years, there has been little advancement in the treatment of the aggressive brain cancer Glioblastoma Multiforme (GBM). This research describes the synthesis of a superparamagnetic iron oxide (SPION)-based nanotheraputic complex for use in targeting and killing aggressive mesenchymal GBM cells. The average sizes and magnetic properties of the synthesized SPIONs are tailored via a novel time-controlled approach to a previously described electrochemical reaction.

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