Historical datasets (1950-2022) of monthly water balance components for the Laurentian Great Lakes.

This study develops a 73-year dataset of water balance components from 1950 to 2022 for the Laurentian Great Lakes Basins. This is carried out using the Large Lakes Statistical Water Balance Model (L2SWBM), which provides a Bayesian statistical framework that assimilates binational input datasets sourced from the United States and Canada. The L2SWBM infers feasible water balance component estimates through this Bayesian framework by constraining the output with a standard water balance equation.

HIF-α signaling regulates the macrophage inflammatory response during infection.

Cutaneous leishmaniasis (CL) contributes significantly to the global burden of neglected tropical diseases, with 12 million people currently infected with parasites. CL encompasses a range of disease manifestations, from self-healing skin lesions to permanent disfigurations. Currently there is no vaccine available, and many patients are refractory to treatment, emphasizing the need for new therapeutic targets.

Synthesis and in vitro evaluation shows disquaramide compounds are a promising class of anti-leishmanial drugs.

An increasing number of treatment failures with current pharmaceutics, as well as a lack of a vaccine, demonstrates the need to develop new treatment options for leishmaniasis. Herein, we describe the synthesis and in vitro analysis of 24 disquaramide compounds targeting the parasite. Of the compounds that were evaluated, six of them ( , , , , , and ) were capable of significantly decreasing the number of parasites by up to 42% compared to the control by day four.

Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis.

Cutaneous leishmaniasis (CL) is a significant public health problem leading to permanently disfiguring skin lesions caused by parasites. Lesion severity stems from an excessive host inflammatory response that prevents healing. Here, we characterized the transcriptional and translational responses of lymphatic endothelial cells (LECs) during murine CL using historical single-cell RNA sequencing data combined with flow cytometry and in vivo puromycin incorporation to assess translational activity.