The Extra-Tumoral Vaccine Effects of Apoptotic Bodies in the Advancement of Cancer Treatment.

The induction of apoptosis in tumor cells is a common target for the development of anti-tumor therapies; however, these therapies still leave patients at increased risk of disease recurrence. For example, apoptotic tumor cells can promote tumor growth and immune evasion via the secretion of metabolites, apoptotic extracellular vesicles, and induction of pro-tumorigenic macrophages. This paradox of apoptosis induction and the pro-tumorigenic effects of tumor cell apoptosis has begged the question of whether apoptosis is a suitable cancer therapy, and led to further explorations into other immunogenic cell death-based approaches.

Utilization of a Solid Waste Inhibitor for the Clean Flotation Enrichment of Phosphate Ores.

The accumulation of phosphogypsum (PG) in the phosphorus chemical industry poses significant environmental challenges. Therefore, developing a harmless utilization method is crucial for alleviating these burdens and promoting sustainable industry practices. In this study, PG was used as a flotation inhibitor, enabling the flotation separation of apatite and dolomite based on the main components and dissolution behavior of PG.

Accumulation of Water-Soluble Polysaccharides during Lychee Pulp Fermentation with Involves Endoglucanase Expression.

In the current work, lychee pulp was subjected to ATCC 14917 fermentation, leading to a substantial increase (2.32-2.67-fold) in water-soluble polysaccharides (WSP).

Clone-Resolved Chemical Depletion of T cells via Cellular Proximity Chemistry.

T cells play a pivotal role in the development of autoimmune diseases. To mitigate autoimmune inflammation without inducing global immunosuppression, it is crucial to selectively eliminate autoreactive T cell clones while preserving the normal T cell repertoire. In this study, we applied cellular proximity chemistry to develop a T-cell depletion method with clonal precision.