Cellular and extracellular white matter alterations after childhood trauma experience in individuals with schizophrenia.

Background: Childhood trauma (CT) is related to altered fractional anisotropy (FA) in individuals with schizophrenia (SZ). However, it remains unclear whether CT may influence specific cellular or extracellular compartments of FA in SZ with CT experience. We extended our previous study on FA in SZ (Costello et al.

Structural brain connectivity does not associate with childhood trauma in individuals with schizophrenia.

Background: Schizophrenia is a brain dysconnectivity disorder. However, it is not well understood whether the experience of childhood trauma (CT) affects dysconnectivity in individuals with schizophrenia (SZ). Using a network-based approach, we examined whether self-reported CT would explain additional variance compared to whole-brain topology and structural connectivity changes in SZ versus healthy controls (HC).

Investigation into the significant role of dermal-epidermal interactions in skin ageing utilising a bioengineered skin construct.

Increased prevalence of skin ageing is a growing concern due to an ageing global population and has both sociological and psychological implications. The use of more clinically predictive in vitro methods for dermatological research is becoming commonplace due to initiatives and the cost of clinical testing. In this study, we utilise a well-defined and characterised bioengineered skin construct as a tool to investigate the cellular and molecular dynamics involved in skin ageing from a dermal perspective.

Experimental assessment of diffusible iodine-based contrast-enhanced computed tomography (diceCT) protocols.

Diffusible iodine-based contrast-enhanced computed tomography (diceCT) is an increasingly used digital complement, supplement, or alternative to traditional dissection-based anatomical research. The diceCT protocol, which has evolved and expanded over the past decade, employs passive diffusion of Lugol's iodine (KI) to increase soft tissue radiodensity and improve structure contrast in the CT or microCT imaging of specimens. The development and application of diceCT has focused largely on specimens under 1 kg, and the varying reporting of methods on studies of both small and large specimens has initiated, but not yet established, an effective diceCT protocol for larger specimens based on monitored experiments of several fundamental variables (.

Do Y'all Say Gay or Trans?: The Impact of Gender and Sexuality on College Students' Experiences in the Rural South.

While national trends indicate improvement in campus climates for LGBTQ+ students, these patterns may not exist on campuses in the Southeast region of the United States, particularly given conservative backlash in the region. Drawing from focus group and survey data, we investigated how students in a rural Southern location perceive campus and community space with regard to safety and support, and how the intersections of gender and sexual orientation affect those perceptions. We found LGBTQ+ students had a mostly positive perception of their campus experience, despite reports of harassment, perceptions of unsafe spaces, and some lack of awareness of resources.