Publications by authors named "L C Carpio"
Article Synopsis
- The apoptosome plays a crucial role in regulating apoptosis through specific interactions between proteins with Caspase Activation and Recruitment Domain (CARD).
- This study conducted a detailed computational analysis to identify key residues involved in the interaction between the CARD domains of Apaf-1 and Caspase-9, highlighting their importance for apoptosome function.
- The findings also revealed that native interactions are more stable than those predicted between different complexes, emphasizing the specificity needed for effective protein interactions in apoptosis regulation.
Objective: To report the outcomes of cats that underwent surgical correction for sialoceles.
Study Design: Multi-institutional retrospective cohort study.
Animals: Twenty-one client-owned cats.
The role of the gut microbiota and its interplay with host metabolic health, particularly in the context of type 2 diabetes mellitus (T2DM) management, is garnering increasing attention. Dipeptidyl peptidase 4 (DPP4) inhibitors, commonly known as gliptins, constitute a class of drugs extensively used in T2DM treatment. However, their potential interactions with gut microbiota remain poorly understood.
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- Uveal melanoma (UM) is the most common eye cancer in adults, with most patients carrying specific gene mutations (GNAQ/GNA11 Q209L/Q209P).
- Researchers believe these mutations can be recognized by the immune system, even in the immune-suppressed environment of the eye.
- Analysis of tumor data shows that Q209L is more likely to trigger an immune response than Q209P, suggesting potential for new treatments, such as vaccines targeting this mutation.