Publications by authors named "L C C Malaquias"
Background: Schistosomiasis is a neglected tropical disease caused by Schistosoma sp., and praziquantel (PZQ) is the first-line treatment. However, traditional PZQ formulations have low solubility and fast metabolism, limiting its effectiveness.
View Article and Find Full Text PDFPseudomonas aeruginosa is an emergent threat due to the antimicrobial resistance crisis. Bacteriophages (phages) are promising agents for phage therapy approaches against P. aeruginosa.
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- Paracoccidioidomycosis (PCM) is a fungal infection caused by various species of the Paracoccidioides fungus, mainly affecting those engaged in rural work.
- The dominant species, Paracoccidioides brasiliensis, has historically been viewed as the primary cause, with research focusing on its interactions with the immune system, including its escape strategies.
- Understanding these interactions and the adhesion molecules used by the fungus can lead to the development of new antifungal treatments aimed at overcoming the challenges posed by the host's immune defenses.
Article Synopsis
- - Paracoccidioidomycosis (PCM) is a serious fungal infection that requires long-term antifungal treatment; this study explored low-level LASER therapy (LLLT) as a potential complementary treatment to enhance recovery.
- - The research involved infecting mice with P. brasiliensis and applying LLLT on alternate days, which resulted in a reduction of cell influx at the infection site while increasing the activation of pro-inflammatory cytokines that help fight the fungus.
- - The findings indicated that LLLT improved healing by decreasing the number of viable fungi and increasing fibrocytes, suggesting that it may benefit PCM patients as an additional treatment option.
Background: Scoliosis is defined as a three-dimensional deformity of the spine characterized by lateral tilt and axial rotation of the vertebrae. Its magnitude in the frontal plane is identified by a Cobb angle greater than 10. The aim of the study was to systematically examine the clinimetric properties of the Spinal Appearance Questionnaire (SAQ) in its cross-cultural adaptations in different languages.
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