Publications by authors named "L C Brody"
Background: Technology-enhanced mental health platforms may serve as a pathway to accessible and scalable mental health care; specifically, those that leverage stepped care models have the potential to address many barriers to patient care, including low mental health literacy, mental health provider shortages, perceived acceptability of care, and equitable access to evidence-based treatment. Driving meaningful engagement in care through these platforms remains a challenge.
Objective: This study aimed to examine predictors of engagement in self-directed digital mental health services offered as part of an employer-based mental health benefit that uses a technology-enabled care platform.
Purpose: The etiopathogenesis of coronal nonsyndromic craniosynostosis (cNCS), a congenital condition defined by premature fusion of 1 or both coronal sutures, remains largely unknown.
Methods: We conducted the largest genome-wide association study of cNCS followed by replication, fine mapping, and functional validation of the most significant region using zebrafish animal model.
Results: Genome-wide association study identified 6 independent genome-wide-significant risk alleles, 4 on chromosome 7q21.
Article Synopsis
- Folate and vitamin B12 are key players in a metabolic process that helps produce important molecules for DNA synthesis, and deficiencies can lead to problems like uracil misincorporation into DNA.
- The study examined how reduced levels of a B12-related enzyme interact with high folic acid diets in mice, focusing on folate distribution and genome stability markers.
- Results showed that high dietary folic acid increased folate levels in some tissues and uracil in DNA, but not significantly in the liver, indicating that high folic acid intake has complex effects on folate metabolism and DNA stability.
Objectives: Approximately 5.5% of the population live with serious mental illnesses (SMI). Older adults with SMI experience a high burden of serious medical illnesses and disparities in advance care planning, symptom management, and caregiver support.
View Article and Find Full Text PDFCholine contributes to the biogenesis of methyl groups, neurotransmitters, and cell membranes. Our genome-wide association study (GWAS) of circulating choline in 2228 college students found that alleles in SLC25A48 (rs6596270) influence choline concentrations in men (p = 9.6 × 10), but not women.
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