Biomarkers.

Background: Neuritic plaques with fibrillar beta-amyloid (Aβ) peptides and tau-protein neurofibrillary tangles, hallmark features of Alzheimer's disease (AD) pathology, have been concomitantly associated with white matter (WM) integrity loss, while a unique effect of each pathology on WM integrity in a more demographically diverse population remains unknown.

Method: To examine the degree to which each pathology affects WM integrity in a more diverse non-demented cohort, Aβ and tau PET, diffusion-weighted imaging (DWI), and cognition (memory and executive function composites) were examined from the U.S.

Public Health.

Background: Multidomain lifestyle interventions have shown promise to slow cognitive decline and possibly prevent dementia. However, challenges arise in analyzing and interpreting treatment response when participants vary in their adherence to intervention components. The U.

Public Health.

Background: The Mediterranean-Dash Intervention for Neurodegenerative Delay (MIND) diet, featuring emphasis on green leafy and other colorful vegetables, berries, unsaturated fats, fish, and whole grains is a major component of the U.S. POINTER multi-domain lifestyle intervention.

Public Health.

Background: The widespread availability of effective disease-modifying therapies would be a breakthrough in slowing the progression of early Alzheimer's disease (AD) to later stages of dementia. The purpose of this study is to explore how primary care capacity, variation in patient care-seeking, and geographic variation in capacity can affect the delivery of AD-modifying therapies.

Method: We used a county-level simulation model to assess patient demand and provider supply for the delivery of AD-modifying therapies.

Public Health.

Background: Behavioral interventions designed to promote healthy lifestyles have the potential to slow biological aging and increase health span. Multidomain interventions that simultaneously target multiple lifestyle behaviors may particularly be promising by increasing the number of interrelated processes that might be benefited. Deficit accumulation frailty indices (FIs) are increasingly used as measures of aging and health status in clinical trials and cohort studies.