Publications by authors named "L C Baak"
Background & Aims: Although primary biliary cholangitis (PBC) is considered a rare disorder, accurate determination of its incidence and prevalence remains challenging due to limited comprehensive population-based registries. We aimed to assess the incidence and prevalence of PBC in the Netherlands over time through the nationwide Dutch PBC Cohort Study (DPCS).
Methods: DPCS retrospectively included every identifiable patient with PBC in the Netherlands from 1990 onwards in all 71 Dutch hospitals.
Background: Perinatal arterial ischemic stroke (PAIS) is associated with adverse neurological outcomes. Quantification of ischemic lesions and consequent brain development in newborn infants relies on labor-intensive manual assessment of brain tissues and ischemic lesions. Hence, we propose an automatic method utilizing convolutional neural networks (CNNs) to segment brain tissues and ischemic lesions in MRI scans of infants suffering from PAIS.
View Article and Find Full Text PDFBackground And Aims: The clinical course of patients with liver cirrhosis and adherence to hepatocellular carcinoma (HCC) screening guidelines are not well studied in the Netherlands. We investigated this and potential risk factors for decompensation and transplant-free survival (TFS) in a large regional cohort.
Methods: We performed a retrospective cohort study of patients with confirmed liver cirrhosis in Amsterdam, the Netherlands.
Article Synopsis
- Perinatal arterial ischemic stroke (PAIS) can lead to long-term neurodevelopmental issues, and this study reviews early predictors of outcomes in infants under four months of age.
- A systematic analysis of 41 studies involving 1395 infants found that MRI assessment of corticospinal tracts and standardized motor assessments are the best predictors of developing cerebral palsy, while techniques like (a)EEG and NIRS may help in predicting cognitive outcomes.
- The study highlights the need for further research to identify effective predictors for non-motor outcomes, such as behavior and language, after PAIS.