Publications by authors named "L Buffat"
The vast array of omics data in microbiology presents significant opportunities for studying bacterial pathogenesis and creating computational tools for predicting pathogenic potential. However, the field lacks a comprehensive, curated resource that catalogs bacterial strains and their ability to cause human infections. Current methods for identifying pathogenicity determinants often introduce biases and miss critical aspects of bacterial pathogenesis.
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- The study provides essential normative values for muscle fiber parameters in children aged 0-18, which are crucial for identifying pathological changes and assessing treatment responses.
- Data was collected from 83 deltoid muscle biopsies that showed variations in muscle morphology—specifically around puberty—with certain parameters influenced by gender only after puberty.
- The research establishes reference charts for muscle fiber types to aid pathology laboratories in diagnosing neuromuscular diseases.
Article Synopsis
- The study investigates the reliability of patch tests for diagnosing contact allergy to Amerchol L-101 (AL-101), a potential marker for lanolin allergy.
- A dose-response re-test was performed on 10 subjects, revealing that 8 exhibited positive allergic reactions, often tied to specific gene activity associated with immune response.
- The findings suggest that while AL-101 is an allergen causing both allergy and irritation, molecular profiling could enhance the accuracy of clinical diagnoses.
Background: Skin exposure to chemicals may induce an inflammatory disease known as contact dermatitis (CD). Distinguishing the allergic and irritant forms of CD often proves challenging in the clinic.
Methods: To characterize the molecular signatures of chemical-induced skin inflammation, we conducted a comprehensive transcriptomic analysis on the skin lesions of 47 patients with positive patch tests to reference contact allergens and nonallergenic irritants.