Simulating combined monoaminergic depletions in a PD animal model through a bio-constrained differential equations system.

Introduction: Historically, Parkinson's Disease (PD) research has focused on the dysfunction of dopamine-producing cells in the substantia nigra pars compacta, which is linked to motor regulation in the basal ganglia. Therapies have mainly aimed at restoring dopamine (DA) levels, showing effectiveness but variable outcomes and side effects. Recent evidence indicates that PD complexity implicates disruptions in DA, noradrenaline (NA), and serotonin (5-HT) systems, which may underlie the variations in therapy effects.

A new framework for polynomial approximation to differential equations.

In this paper, we discuss a framework for the polynomial approximation to the solution of initial value problems for differential equations. The framework is based on an expansion of the vector field along an orthonormal basis, and relies on perturbation results for the considered problem. Initially devised for the approximation of ordinary differential equations, it is here further extended and, moreover, generalized to cope with constant delay differential equations.

A multiregional extension of the SIR model, with application to the COVID-19 spread in Italy.

The paper concerns a new forecast model that includes the class of undiagnosed infected people, and has a multiregion extension, to cope with the in-time and in-space heterogeneity of an epidemic. The model is applied to the SARS-CoV2 (COVID-19) pandemic that, starting from the end of February 2020, began spreading along the Italian peninsula, by first attacking small communities in north regions, and then extending to the center and south of Italy, including the two main islands. It has proved to be a robust and reliable tool for the forecast of the total and active cases, which can be also used to simulate different scenarios.

Doppler-guided transanal haemorrhoidal dearterialization for haemorrhoids: results from a multicentre trial.

Aim: This multicentre study, based on the largest patient population ever published, aims to evaluate the efficacy of Doppler-guided transanal haemorrhoidal dearterialization (THD Doppler) in the treatment of symptomatic haemorrhoids and to identify the factors predicting failure for an effective mid-term outcome.

Method: Eight hundred and three patients affected by Grade II (137, 17.1%), III (548, 68.

Anti free radical action of calcium antagonists and H1 and H2 receptors antagonists in neoplastic disease.

The blood of the subjects suffering from Neoplastic Disease (ND) shows phenomena of membrane peroxidation due to the presence of Free Radicals (FRs), in a quantity much greater than the one observed in the blood of healthy subjects. This can be detected either by calculating the time necessary for the formation of "Heinz bodies" (Hbs), (p < 0.00001) after oxidative stress of the blood in vitro with acetylphenylidrazine (APH), or by calculating the methemoglobin (metHb) quantity that forms after the same treatment (P < 0.