Publications by authors named "L Bruce Pearce"
A long-standing aim in the setting of various pathologies including acute myocardial infarction, chronic kidney disease (CKD), and ischaemic stroke, has been to identify successful approaches to augment cellular and organ protection. Although the continual evolution and refinement of ideas over the past few decades has allowed the field to progress, we are yet to realise successful clinical translation of this concept. The 12th Hatter Cardiovascular Workshop identified a number of important points and key questions for future research relating to cardio- and neuro-protection and interorgan communication.
View Article and Find Full Text PDFAstronomers have found more than a dozen planets transiting stars that are 10-40 million years old, but younger transiting planets have remained elusive. The lack of such discoveries may be because planets have not fully formed at this age or because our view is blocked by the protoplanetary disk. However, we now know that many outer disks are warped or broken; provided the inner disk is depleted, transiting planets may thus be visible.
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- The study evaluated intraretinal microvascular abnormalities (IRMA) in eyes with advanced nonproliferative diabetic retinopathy (NPDR), focusing on their correlation with other retinal changes like ischemia and microaneurysms.
- The research involved 60 eyes from patients with type 2 diabetes, using various imaging techniques (color fundus photography, ultra wide field fluorescein angiography, and swept-source optical coherence tomography) to identify IRMA, particularly in the central retina.
- Results showed that ultra wide field fluorescein angiography was the most effective method for detecting IRMA, finding more abnormalities than the other imaging techniques, with a significant association between IRMA and microaneurysms.
Genetic diversity is rapidly lost from small, isolated populations by genetic drift. Measuring the level of genetic drift using effective population size ( ) is highly useful for management. Single-cohort genetic estimators approximate the number of breeders in one season ( ): a value < 100 signals likely inbreeding depression.
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- Older adults (65+) represent a significant portion of emergency laparotomy cases in the UK, yet there's limited data on patients who require surgery but do not undergo it, referred to as NoLap patients.
- A study across 64 surgical centers tracked 750 NoLap patients over a 90-day period and found that 60% were female with a median age of 83, most suffering from frailty and severe comorbidities, leading to a high 90-day mortality rate of 79%.
- The findings highlight the complex medical challenges faced by NoLap patients, with a small percentage surviving long-term but requiring increased care, emphasizing the need for further research on the decision-making process surrounding surgery in this high-risk group.