Neuroprotective effects of AT1 receptor antagonists after experimental ischemic stroke: what is important?

The present study conducted in rats defines the requirements for neuroprotective effects of systemically administered AT1 receptor blockers (ARBs) in acute ischaemic stroke. The inhibition of central effects to angiotensin II (ANG II) after intravenous (i.v.

Digital breast tomosynthesis-guided vacuum-assisted breast biopsy: initial experiences and comparison with prone stereotactic vacuum-assisted biopsy.

Purpose: To use digital breast tomosynthesis (DBT)-guided vacuum-assisted biopsy (VAB) to sample target lesions identified at full-field digital screening mammography and compare clinical performance with that of prone stereotactic (PS) VAB.

Materials And Methods: In this institutional review board-approved study, 205 patients with 216 mammographic findings suspicious for cancer were scheduled to undergo mammography-guided VAB. Written informed consent was obtained.

A receptor fusion protein for the inhibition of murine oncostatin M.

Background: Most cytokines signal through heteromeric receptor complexes consisting of two or more different receptor subunits. Fusion proteins of the extracellular parts of receptor subunits turned out to be promising cytokine inhibitors useful in anti-cytokine therapy and cytokine research.

Results: We constructed receptor fusion proteins (RFP) consisting of the ligand binding domains of the murine oncostatin M (mOSM) receptor subunits mOSMR and mgp130 connected by a flexible linker as potential mOSM inhibitors.

Short- and long-contact therapy using a new dithranol formulation in individually adjusted dosages in the management of psoriasis.

This study compares two treatment regimens, short- and long-contact dithranol in individually adjusted dosages, using a new formulation (Micanol) in the management of psoriasis. It was designed as a six week, randomized, open, parallel groups study. Twenty-two in-patients and 27 out-patients were included with either plaque type or small patch type of psoriasis.

A novel dithranol formulation in the over night treatment of psoriasis at home.

The objective of this study was to compare the clinical efficacy and acceptability of two dithranol creams (Micanol and Amitase) in patients with plaque type psoriasis treating themselves daily at home. Thirty-five patients started with Amitase (0.1%) and 37 with Micanol (0.