Publications by authors named "L Brockley"
Article Synopsis
- An 8-year-old Australian Silky Terrier exhibited symptoms like lethargy, shaking, and lack of appetite, leading to a veterinary visit where a rectal mass was discovered.
- The mass was surgically removed and identified as a low-grade mast cell tumor (MCT) with a mitotic count of 0, suggesting less aggressive behavior.
- Following the surgery, the dog underwent a chemotherapy regimen and, 30 weeks later, showed no signs of tumor recurrence and remained healthy at the 9-month mark, indicating a potentially better prognosis than previously reported for similar cases.
Liquid biopsies have emerged as a promising tool for the detection of metastases as well as local and regional recurrence in lung cancer. Liquid biopsy tests involve analyzing a patient's blood, urine, or other body fluids for the detection of biomarkers, including circulating tumor cells or tumor-derived DNA/RNA that have been shed into the bloodstream. Studies have shown that liquid biopsies can detect lung cancer metastases with high accuracy and sensitivity, even before they are visible on imaging scans.
View Article and Find Full Text PDFLung cancer detection and monitoring are hampered by a lack of sensitive biomarkers, which results in diagnosis at late stages and difficulty in tracking response to treatment. Recent developments have established liquid biopsies as promising non-invasive methods for detecting biomarkers in lung cancer patients. With concurrent advances in high-throughput sequencing technologies and bioinformatics tools, new approaches for biomarker discovery have emerged.
View Article and Find Full Text PDFLung cancer and chronic obstructive pulmonary disease (COPD) often co-occur, and individuals with COPD are at a higher risk of developing lung cancer. While the underlying mechanism for this risk is not well understood, its major contributing factors have been proposed to include genomic, immune, and microenvironment dysregulation. Here, we review the evidence and significant studies that explore the mechanisms underlying the heightened lung cancer risk in people with COPD.
View Article and Find Full Text PDFLung cancer is one of the most frequent tumors that metastasize to the brain. Brain metastasis (BM) is common in advanced cases, being the major cause of patient morbidity and mortality. BMs are thought to arise via the seeding of circulating tumor cells into the brain microvasculature.
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