Publications by authors named "L Bridges"
Background: Diffuse hemispheric glioma, histone 3 (H3) G34-mutant, has been newly defined in the 2021 WHO classification of central nervous system tumors. Here we sought to define the prognostic roles of clinical, neuroimaging, pathological, and molecular features of these tumors.
Methods: We retrospectively assembled a cohort of 114 patients (median age 22 years) with diffuse hemispheric glioma, H3 G34-mutant, CNS WHO grade 4 and profiled the imaging, histological and molecular landscape of their tumors.
Article Synopsis
- Integrated behavioral health programs, like the PHLOW Program, help reduce costs and improve patient outcomes, but funding challenges hinder their widespread adoption.
- The PHLOW Program uses a collaborative care model to provide accessible psychiatric care through primary care providers, demonstrating effective patient outcomes through brief episodes of care.
- Results show reductions in anxiety and depression, lower mental health claims, and increased financial support, suggesting a viable model for other organizations to implement similar integrated behavioral health programs.
Current society guidelines recommend purse-string closure technique for stoma reversal, which has been shown to reduce but not eliminate the risk of deep surgical site infection (SSI) at the original stoma site, a complication associated with increased morbidity and cost. We studied an adjunctive technique to further reduce the risk of SSI. A retrospective chart review was conducted on adult patients who underwent stoma reversal between May 2016 - July 2022.
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- * In the OpenSAFELY-TPP database, 78.2% of patients had their ethnicity recorded in primary care as of January 2022, with higher rates in women and those with serious health conditions.
- * The primary care ethnicity data closely matched the 2021 UK census data, with a high consistency found among patients with multiple ethnicity records, particularly indicating issues with classification for those recorded as "Other."
Article Synopsis
- - The study examines how the Covid-19 pandemic influenced the rates of group A streptococcal infections and related antibiotic prescriptions in primary care practices across England from January 2018 to March 2023.
- - Significant findings show that infections and antibiotic prescriptions peaked in December 2022, surpassing levels seen during the 2017-18 season, with notable increases in rates for sore throat, scarlet fever, and invasive infections.
- - The research highlights a concerning trend, reporting that the rate ratios for infections and prescriptions in the 2022-23 season were considerably higher compared to the pre-pandemic period, suggesting lasting impacts from the pandemic on public health.