Publications by authors named "L Bricaire"
C-peptide level concomitant with hypoglycemia gives better performances than insulin for the diagnosis of endogenous hyperinsulinism: a single-center study of 159 fasting trials.
Eur J Endocrinol
February 2023
Introduction: Diagnosis of endogenous hyperinsulinism relies on the occurrence of a hypoglycemia, concomitant with inadequate high insulin and C-peptide levels. However, diagnostic cutoffs are not consensual among the different learned societies. The objective of this work was to propose optimized cutoffs for these three parameters for the diagnosis of endogenous hyperinsulinism.
View Article and Find Full Text PDFObjective: Pneumocystis pneumonia (PcP) is an opportunistic infection occurring in immunocompromised patients. Cushing's syndrome (CS) impairs the immune system, and several authors have reported PcP in patients with CS. The present study aimed to characterize PcP occurring in a CS context and its management in French tertiary centers, in order to highlight the similarities in clinical presentation and treatment according to whether prophylaxis is implemented or not.
View Article and Find Full Text PDFArticle Synopsis
- Osilodrostat is a new medication that inhibits 11β-hydroxylase, similar to Metyrapone, and the study aimed to compare their effects on steroid levels in patients with ACTH-dependent Cushing's syndrome.* -
- Nineteen patients received Osilodrostat, while eight were treated with Metyrapone; results showed that Osilodrostat led to lower cortisol and testosterone levels, with hypocortisolism occurring in 48% of its users versus 7% for Metyrapone.* -
- The findings indicate that Osilodrostat is less selective in inhibiting steroid-producing enzymes compared to Metyrapone, which might explain the differences
Article Synopsis
- The study focuses on primary bilateral macronodular adrenal hyperplasia (PBMAH), a condition linked to adrenal macronodules and excess cortisol levels, highlighting the role of ARMC5 gene mutations as a key factor.
- Out of 352 patients analyzed, 52 (14.8%) were found to have ARMC5 mutations, exhibiting significantly higher cortisol levels and larger adrenal glands compared to non-mutated patients.
- The research identifies specific criteria—bilateral adrenal involvement and autonomous cortisol secretion—that are highly predictive of ARMC5 mutations, suggesting that these criteria should guide genetic testing and help refine diagnostic standards for PBMAH.