Publications by authors named "L Brcic"
This report describes a rare occurrence of benign fibrous histiocytoma in the frontal sinus of a 38-year-old male. The patient presented with acute symptoms, including sudden-onset headache, nausea, and general discomfort, although neurological, otorhinolaryngological and laboratory examinations showed no abnormalities. A cranial CT scan revealed a cystic, osteodestructive lesion measuring 2.
View Article and Find Full Text PDFObjectives: Evaluating invasion in non-mucinous adenocarcinoma (NMA) of the lung is crucial for accurate pT-staging. This study compares the World Health Organization (WHO) with a recently modified NMA classification.
Materials And Methods: A retrospective case-control study was conducted on small NMA pT1N0M0 cases with a 5-year follow-up.
: Pleural mesothelioma (PM) is a rare type of cancer with poor prognosis. Prognostic and predictive biomarkers could improve treatment strategies in these patients. Programmed death ligand 1 (PD-L1), integrin-linked kinase (ILK) and breast cancer gene 1-associated protein (BAP-1) have been proposed to predict outcomes in PM, but existing data are limited and controversial.
View Article and Find Full Text PDFBackground: Apart from fusions and the common mutations, targetable molecular alterations are irrelevant for adjuvant treatment decision making in early-stage non-small cell lung cancer (NSCLC). This retrospective analysis aimed to investigate if there is a difference in recurrence-free survival in stage I-III NSCLC harboring druggable molecular alterations compared to subtypes without targetable molecular alterations.
Methods: All consecutive patients who underwent surgery with curative intent for NSCLC (stage I-III) with targetable mutations between January 2015 and December 2020 at three Austrian institutions were identified and compared with tumors without targetable molecular alterations.
Article Synopsis
- The study aims to understand how specific molecular changes, particularly the expression of a certain gene, influence the clinical outcomes of patients with pulmonary carcinoids, which can range from slow-growing to deadly tumors.
- Researchers analyzed RNA sequencing data from two cohorts of pulmonary carcinoid patients (totaling 193) to determine the prognostic value of this gene expression and its relationship with telomerase activity, which is linked to tumor aggressiveness.
- Results showed that high expression of the gene correlates with worse survival rates and is an independent predictor of poor clinical outcomes, suggesting that it could be a key factor in assessing the severity of pulmonary carcinoids.