A phase 2 multimodality trial of docetaxel/prednisone with sunitinib followed by salvage radiation therapy in men with PSA recurrent prostate cancer after radical prostatectomy.

Background: In men with high Gleason PC and rapid PSA progression after surgery, failure rates remain unacceptably high despite salvage radiation. We explored a novel multimodality approach of docetaxel with anti-angiogenic therapy before salvage radiotherapy (RT).

Methods: This was a phase 2 single-arm prospective open-label trial with historic controls.

Financial crisis in a family practice residency: a successful strategy.

A family practice residency program in a California public teaching hospital was faced with a financial crisis that threatened its elimination. Hospital officials and medical leaders developed a strategy that resulted in (1) personnel reductions focused principally on hospital overhead departments, (2) reductions in faculty teaching fees, (3) increased resident and faculty productivity, (4) increased patient access to ambulatory areas, (5) decreased utilization of laboratory, radiology, respiratory, physical therapy, pharmacy, and cardiology services, and (6) more favorable contracts with providers for patient care services. The hospital met its financial objectives primarily as a result of collaborative efforts of the hospital management team and a committed faculty vested in the success of the institution.

Zinc and vitamin A: serum concentrations of zinc and retinol-binding protein (RBP) in healthy adolescents.

The concentrations of serum zinc and retinol-binding protein (RBP) have been studied with special reference to pubertal development in 132 healthy adolescents and young adults (11-26 years of age). The RBP level remained low during the first three of the five stages of puberty (mean, about 30 mg/l). When puberty degree 4 had been reached, the mean RBP level increased to nearly adult values (about 40 mg/l), the boys having somewhat higher levels than the girls.

Some aspects of the intestinal absorption of zinc in man.

Serum zinc concentrations in peripheral venous blood were determined in 8 healthy volunteers at various times after oral administration of 50 mg Zn++. The same dose was given to 6 patients surgically treated for obesity by jejuno-ileostomy. In the healthy volunteers the mean serum zinc concentration before dosing was 0.