Publications by authors named "L Brash"
Article Synopsis
- The Birmingham Hip Resurfacing (BHR) technique was developed in 1997 to cater to young, active patients, showing effective survival rates even after 25 years of follow-up on the original 130 patient cohort.
- Overall implant survival reached 83.5% at 25 years, with male patients faring better (89.5%) compared to females (66.9%), while failures were primarily due to metal debris reactions and femoral neck fractures.
- The study concludes that BHR offers a lasting alternative to total hip arthroplasty, especially beneficial for younger patients needing hip replacement.*
Background: Many worldwide regulatory authorities recommend regular surveillance of metal-on-metal hip arthroplasty patients given high failure rates. However, concerns have been raised about whether such regular surveillance, which includes asymptomatic patients, is evidence-based and cost-effective. We determined: (1) the cost of implementing the 2015 MHRA surveillance in "at-risk" Birmingham Hip Resurfacing (BHR) patients; and (2) how many asymptomatic hips with adverse reactions to metal debris (ARMD) would have been missed without patient recall.
View Article and Find Full Text PDFWe investigated whether blood metal ions could effectively identify bilateral metal-on-metal total hip arthroplasty (THA) patients at risk of adverse reactions to metal debris (ARMD). Whole blood metal ions were sampled in 50 patients with bilateral 36mm Corail-Pinnacle THAs. Patients were divided into ARMD (n=10) and non-ARMD groups (n=40), with optimal ion thresholds for identifying ARMD determined using receiver operating characteristic analysis.
View Article and Find Full Text PDFApelin agonism causes systemic vasodilatation and increased cardiac contractility in humans, and improves pulmonary arterial hypertension (PAH) in animal models. Here, the authors examined the short-term pulmonary hemodynamic effects of systemic apelin infusion in patients with PAH. In a double-blind randomized crossover study, 19 patients with PAH received intravenous (Pyr)apelin-13 and matched saline placebo during invasive right heart catheterization.
View Article and Find Full Text PDFAims: We investigated whether blood metal ion levels could effectively identify patients with bilateral Birmingham Hip Resurfacing (BHR) implants who have adverse reactions to metal debris (ARMD).
Patients And Methods: Metal ion levels in whole blood were measured in 185 patients with bilateral BHRs. Patients were divided into those with ARMD who either had undergone a revision for ARMD or had ARMD on imaging (n = 30), and those without ARMD (n = 155).