Publications by authors named "L Bowler"
Objective: The roll-out of the Pfizer-BioNTech BNT162b2 COVID-19 vaccine has brought many logistical challenges, such as the absence of comprehensive stability data leading to strict handling instructions during dilution and administration. Accidental mishandling therefore presents challenging clinical dilemmas, which often led vaccine providers to err on the side of caution and discard mishandled vials rather than risk administering ineffective vaccine. This study aims to answer key questions about the vaccine's stability to allow for a more informed decision-making process should a non-conformity occur.
View Article and Find Full Text PDFAgeing is associated in many organisms with a reduction in motor movements. We have previously shown that the rate of feeding movements of the pond snail, Lymnaea, decreased with age but the underlying cause is not fully understood. Here, we show that dopamine in the cerebro-buccal complex is an important signalling molecule regulating feeding frequency in Lymnaea and that ageing is associated with a decrease in CNS dopamine.
View Article and Find Full Text PDFArticle Synopsis
- Chaste is an open-source simulation package designed for solving mathematical models related to physiology and biology, focusing on areas such as cardiac electrophysiology, soft tissue modeling, and lung ventilation.
- Cardiac Chaste offers a high-performance, verified simulation tool for accurate heart modeling, while Cell-based Chaste provides extensible frameworks for simulating biological tissues through various cellular models.
- Lung Chaste presents a novel software package that integrates detailed airway mechanics with overall lung ventilation, making it available for researchers and enhancing understanding of tissue growth and repair in biology.