Publications by authors named "L Bouslama"
Brown seaweeds are known for their bioactive compounds, particularly sulfated polysaccharides such as fucoidans, which have demonstrated antiviral properties. However, limited studies have focused on the antiviral potential of fucoidans extracted from Mediterranean brown seaweeds. In this study, two brown seaweeds Padina pavonica and Dictyopteris membranacea (Fuc-Pad and Fuc-Dic) were collected from monastir coasts, Tunisia, and a specific extraction protocol was employed to obtain fucoidans.
View Article and Find Full Text PDFAn easy and efficient approach for the synthesis of highly regioselective functionalized dihydronaphthalen-1(2)-one family of α-tetralones from functionalized tetralone precursors which derived from Morita-Baylis-Hillman (MBH) adducts as starting substrates has been developed. The target dihydronaphthalen-1(2)-ones are obtained through the oxidation of tetrahydronaphthalenes (THN) using DDQ as the oxidizing agent, conducted in aqueous acetic acid at reflux conditions. The yields obtained ranged from 90 to 98%.
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- - The study explored the antibacterial and antileishmanial effects of Micromeria nervosa extracts, identifying ursolic acid as the active compound and examining its molecular mechanism of action.
- - Ethanol and diethyl ether extracts of the plant were tested, with the diethyl ether extract showing strong antibacterial activity against certain resistant bacteria and significant antileishmanial effects against Leishmania species.
- - Results suggest that M. nervosa extracts and the identified ursolic acid could serve as potential natural alternatives for treating infections, demonstrating low toxicity against host cells and targeting specific gene expressions in pathogens.
Due to the numerous side effects of conventional drugs against herpetic infections and the growing phenomenon of resistance, the researchers turned to natural compounds as a source of new drugs because they are less toxic than the synthetic molecules. This study aimed to analyse the activity of male floral bud extracts, against the replication of herpes simplex virus type 2, as well as to investigate their mode of action, isolate, and identify the active compound. Cell viability and anti-herpes virus activity were performed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and the plaque reduction assay, respectively.
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- The study investigates the antiviral potential of methanolic extracts from two edible mushrooms against Herpes Simplex Virus type 2 and Coxsackie Virus B type 3.
- The extracts were found to be non-cytotoxic at high doses and showed effective viral inhibition with notable selectivity indices, particularly against HSV-2.
- Inonotusin A, a compound identified from the extracts, is highlighted as a novel antiviral agent with potential for clinical use, marking the first exploration of its antiviral properties.