Publications by authors named "L Bosisio"
Subclinical rhythmic electrographic discharge of adults (SREDA) is one of the rarest and most challenging non-epileptic electroencephalographic variants. Although the pathogenesis of this activity is unclear, an association with vascular insufficiency and cerebral hypoxia has been proposed. SREDA usually occurs in adulthood, but there are few reports in the pediatric population.
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- Pediatric multiple sclerosis (MS) has distinct features compared to adult MS and this study used advanced MRI techniques to analyze white matter lesions over 12 months in young patients.
- Eleven pediatric MS patients were examined, and the findings highlighted the presence of paramagnetic rim lesions and a significant percentage of iso-/hypo-intense lesions, which likely reflect the disease's inflammatory nature.
- The study concluded that chronic inflammation appears early in pediatric MS, and the high prevalence of certain lesion types may indicate better remyelination potential in younger patients.
Objective: Cerebral cavernous malformations (CCMs) are cerebral vascular lesions that occasionally occur with seizures. We present a retrospective case series from IRCCS Gaslini Children's Hospital, a systematic review, and meta-analysis of the literature with the goal of elucidating the post-surgery seizure outcome in children with CCMs.
Methods: a retrospective review of children with cavernous malformation related epilepsy who underwent surgery at Gaslini Children's Hospital from 2005 to 2022 was conducted.
Objective: Negative MRI and an epileptogenic zone (EZ) adjacent to eloquent areas are two main issues that can be encountered during pre-surgical evaluation for epilepsy surgery. Focal Cortical Dysplasia type II (FCD type II) is the most common aetiology underlying a negative MRI. The objective of this study is to present three cases of pediatric patients exhibiting negative MRI and a seizure onset zone close to eloquent areas, who previously underwent traditional open surgery or SEEG-guided radiofrequency thermocoagulations (RF-TC).
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- The occurrence of combined central and peripheral demyelination (CCPD) is uncommon, primarily documented in small studies focused on adults.
- A case study of a 7-year-old girl illustrates the potential for anti-MOG antibody positivity to vary and links to a diagnosis of MOGAD associated with CCPD.
- Clinicians should consider CCPD in children when assessing atypical demyelination cases, as this awareness can influence diagnosis and treatment strategies.