Publications by authors named "L Born"
Purpose: Gene-based therapies for inherited retinal dystrophies (IRDs) are upcoming. Treatment before substantial vision loss will optimize outcomes. It is crucial to identify common phenotypes and causative genes in children.
View Article and Find Full Text PDFAims: This study aimed to evaluate the effectiveness of somatostatin analogues (SA) for cystoid maculopathy (CM) in retinitis pigmentosa (RP) patients.
Materials And Methods: In this retrospective case series, clinical and imaging characteristics of 28 RP patients with CM, unresponsive to carbonic anhydrase inhibitors, were collected from medical charts. All patients received SA treatment as an alternative (octreotide long-acting release at 20 mg/month or 30 mg/month, or lanreotide at 90 mg/month or 120 mg/month).
Purpose: We investigated the natural history of retinal dystrophy owing to variants in the MYO7A gene.
Methods: Fifty-three patients (mean age, 33.6 ± 16.
A cohort study of 19 patients with gyrate atrophy of the choroid and retina (GACR).
Graefes Arch Clin Exp Ophthalmol
November 2024
Article Synopsis
- Gyrate atrophy of the choroid and retina (GACR) is a genetic disorder that causes progressive eye degeneration and significant vision loss, highlighting the importance of understanding its clinical characteristics for future treatments.
- A study of 19 patients showed an early onset of eye symptoms, with many requiring cataract surgery by their late twenties, and demonstrated a link between early dietary protein restriction and improved outcomes in some cases.
- The findings stress the severe nature of GACR, including complications like severe myopia and cystoid maculopathy, underlining the need for early diagnosis to facilitate timely interventions and improve patient quality of life.